ArticleInternational journal of pancreatology : official journal of the International Association of Pancreatology2000
Does mortality occur early or late in acute pancreatitis?
Article in International journal of pancreatology : official journal of the International Association of Pancreatology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 3 of them syntheses that pooled it.
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Who cites it
35 citing papers in PubMed, 3 syntheses or guidelines pooled it, 134 citations in OpenAlex.
- American College of Gastroenterology Guidelines: Management of Acute Pancreatitis.The American journal of gastroenterology · 2024Guideline
- Early routine endoscopic retrograde cholangiopancreatography strategy versus early conservative management strategy in acute gallstone pancreatitis.The Cochrane database of systematic reviews · 2012Pooled it
- JPN Guidelines for the management of acute pancreatitis: epidemiology, etiology, natural history, and outcome predictors in acute pancreatitis.Journal of hepato-biliary-pancreatic surgery · 2006Guideline
- Persistent pancreatic enzyme elevation is correlated with superinfection in acute pancreatitis with fluid collections: a prospective, multicentre cohort analysis.Frontiers in cellular and infection microbiology · 2026Article
- Nonlinear association between hematocrit levels and short-term all-cause mortality in ICU patients with acute pancreatitis: insights from a retrospective cohort study.BMC gastroenterology · 2025Article
- Rectal 5-aminosalicylic acid induced pancreatitis in a patient with newly diagnosed ulcerative colitis.Clinical journal of gastroenterology · 2025Article
- Article
- Nucleated red blood cell distribution in critically ill patients with acute pancreatitis: a retrospective cohort study.BMC gastroenterology · 2024Article
- Guidelines for Antibiotics Prescription in Critically Ill Patients.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2024Article
- Article
- Article
- Pulmonary Artery Catheter in Patients with Severe Acute Pancreatitis: A Single-Center Retrospective Study.Digestive diseases and sciences · 2022Article
- Effect of abdominal visceral fat on mortality risk in patients with severe acute pancreatitis.JGH open : an open access journal of gastroenterology and hepatology · 2021Article
- Systemic Immune-Inflammation Index for Predicting the Prognosis of Critically Ill Patients with Acute Pancreatitis.International journal of general medicine · 2021Article
- Article
- Severity stratification and prognostic prediction of patients with acute pancreatitis at early phase: A retrospective study.Medicine · 2019Article
- Guidelines for Antibiotic Prescription in Intensive Care Unit.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2019Article
- Incidence and epidemiological features of acute pancreatitis among adult inhabitants in Qatar.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2019Article
- Disease Course Differences in Acute Pancreatitis Based on Etiology Using the Pancreatitis Activity Scoring System.Pancreas · 2018Article
- Serial evaluation of the SOFA score is reliable for predicting mortality in acute severe pancreatitis.Medicine · 2018Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledSeveral prior studies have suggested that 80% of deaths in acute pancreatitis occur late as a result of pan-creatic infection. Others have suggested that approx half of deaths occur early as a result of multisystem organ failure. The aim of the present study was to determine the timing of mortality of acute pancreatitis at a large tertiary-care hospital in the United States.
methodsPatients with a diagnosis of acute pancreatitis (ICD-9 code 577.0) admitted to Brigham and Women's Hospital from October 1, 1982 to June 30, 1995 were retrospectively studied to determine total mortality, frequency of early vs late deaths, and clinical features of patients with early (< or = 14 d after admission) or late deaths (> 14 d after admission).
resultsThe overall mortality of acute pancreatitis was 2.1% (17 deaths among 805 patients). Eight deaths (47%) occurred within the first 14 d of hospitalization (median d 8, range 1-11 d), whereas 9 occurred after 14 d (median d 56, range 19-81). Early deaths resulted primarily from organ failure. Late deaths occurred postoperatively in 8 patients with infected or sterile necrosis and 1 patient with infected necrosis treated medically.
conclusionApproximately half of deaths in acute pancreatitis occur within the first 14 d owing to organ failure and the remainder of deaths occur later because of complications associated with necrotizing pancreatitis. Improvement in mortality in the future will require innovative approaches to counteract early organ failure and late complications of necrotizing pancreatitis.
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