ArticleMolecular psychiatry2000
A genome-wide autosomal screen for schizophrenia susceptibility loci in 71 families with affected siblings: support for loci on chromosome 10p and 6.
Article in Molecular psychiatry, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
55 citing papers in PubMed, 3 syntheses or guidelines pooled it, 169 citations in OpenAlex.
- Pooled it
- Meta-analysis of 32 genome-wide linkage studies of schizophrenia.Molecular psychiatry · 2009Pooled it
- Meta-analysis of whole-genome linkage scans of bipolar disorder and schizophrenia.Molecular psychiatry · 2002Pooled it
- Genetic investigation of chromosome 5q GABAA receptor subunit genes in schizophrenia.Molecular psychiatry · 2005Trial
- Shared and specific susceptibility loci for schizophrenia and bipolar disorder: a dense genome scan in Eastern Quebec families.Molecular psychiatry · 2005Trial
- Genetic polymorphisms of PIP5K2A and course of schizophrenia.BMC medical genetics · 2020Article
- Molecular Variants in Human Trace Amine-Associated Receptors and Their Implications in Mental and Metabolic Disorders.Cellular and molecular neurobiology · 2020Review
- Pro-inflammatory cytokines and their epistatic interactions in genetic susceptibility to schizophrenia.Journal of neuroinflammation · 2016Article
- Replication of association between schizophrenia and chromosome 6p21-6p22.1 polymorphisms in Chinese Han population.PloS one · 2013Article
- Genome-wide association study of multiplex schizophrenia pedigrees.The American journal of psychiatry · 2012Article
- Transcriptome sequencing revealed significant alteration of cortical promoter usage and splicing in schizophrenia.PloS one · 2012Article
- Dysbindin-1, WAVE2 and Abi-1 form a complex that regulates dendritic spine formation.Molecular psychiatry · 2010Article
- Genome-wide linkage using the Social Responsiveness Scale in Utah autism pedigrees.Molecular autism · 2010Article
- Suggestive linkage of the child behavior checklist juvenile bipolar disorder phenotype to 1p21, 6p21, and 8q21.Journal of the American Academy of Child and Adolescent Psychiatry · 2010Article
- Association analysis of the PIP4K2A gene on chromosome 10p12 and schizophrenia in the Irish study of high density schizophrenia families (ISHDSF) and the Irish case-control study of schizophrenia (ICCSS).American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2010Article
- Clustering by neurocognition for fine mapping of the schizophrenia susceptibility loci on chromosome 6p.Genes, brain, and behavior · 2009Article
- Epigenetic mechanisms in schizophrenia.Biochimica et biophysica acta · 2009Review
- Genomewide linkage scan of schizophrenia in a large multicenter pedigree sample using single nucleotide polymorphisms.Molecular psychiatry · 2009Article
- Is the histidine triad nucleotide-binding protein 1 (HINT1) gene a candidate for schizophrenia?Schizophrenia research · 2008Article
- Genomic structural variation and schizophrenia.Current psychiatry reports · 2008Review
Corrections and comments
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Authors and funding
15 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Evidence from epidemiological studies and segregation analysis suggests oligo- or polygenic inheritance in schizophrenia. Since model independent methods are thought to be most appropriate for linkage analysis in complex disorders, we performed a genome-wide autosomal screen in 71 families from Germany and Israel containing 86 independent affected sib-pairs with parental genotype information for statistical analysis strictly identity by descent. We genotyped 305 individuals with 463 markers at an average distance of approximately 10 cM genome-wide, and 1-2 cM in candidate regions (5q, 6p, q, 8p, 10p, 18p, 22q). The highest multipoint LOD scores (ASPEX) were obtained on 6p (D6S260, LOD = 2.0; D6S274, LOD = 2.2, MHC region, LOD = 2.15) and on 10p (D10S1714, LOD = 2.1), followed by 5q (D5S2066, LOD = 1.36), 6q (D6S271, LOD = 1.12; D6S1613, LOD = 1.11), 1q (D1S2675, LOD = 1.04), and 18p (broad disease model: D18S1116, LOD = 1.0). One hundred and thirty-three additional family members were available for some of the families (extended families) and were genotyped for these regions. GENEHUNTER produced a maximum NPL of 3.3 (P = 0.001) for the MHC region and NPL of 3.13 (P = 0.0015) for the region on 10p. There is support for these regions by independent groups. In genome-wide TDT analysis (sTDT, implemented in ASPEX), no marker passed the significance level of 0.0001 given by multiple testing, but nominal significance values for D10S211 (P = 0.03) and for GOLF (P = 0.0032) support further the linkage results on 10p and 18p. Our survey of 22 chromosomes identified candidate regions which should be useful to screen for schizophrenia susceptibility genes.
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