ReviewMolecular psychiatry2000
Cytokine and growth factor involvement in schizophrenia--support for the developmental model.
Review in Molecular psychiatry, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 195 citations in OpenAlex.
- Association of IL1B Gene Polymorphisms (rs1143634 and rs16944) with Schizophrenia in Iranian Patients.Biochemical genetics · 2026Article
- Neurobiology of COVID-19-Associated Psychosis/Schizophrenia: Implication of Epidermal Growth Factor Receptor Signaling.Neuropsychopharmacology reports · 2025Review
- Chronic haloperidol administration downregulates select BDNF transcript and protein levels in the dorsolateral prefrontal cortex of rhesus monkeys.Frontiers in psychiatry · 2023Article
- Von Economo neurons: Cellular specialization of human limbic cortices?Journal of anatomy · 2022Review
- Schizophrenia is defined by cell-specific neuropathology and multiple neurodevelopmental mechanisms in patient-derived cerebral organoids.Molecular psychiatry · 2022Article
- Creative Destruction: A Basic Computational Model of Cortical Layer Formation.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Perinatal complications and executive dysfunction in early-onset schizophrenia.BMC psychiatry · 2020Article
- Therapeutic Microbiology: The Role ofNutrients · 2018Review
- Bidirectional Microglia-Neuron Communication in Health and Disease.Frontiers in cellular neuroscience · 2018Review
- Observational
- A Whole Methylome CpG-SNP Association Study of Psychosis in Blood and Brain Tissue.Schizophrenia bulletin · 2016Article
- Effects of prenatal Poly I:C exposure on global histone deacetylase (HDAC) and DNA methyltransferase (DNMT) activity in the mouse brain.Molecular biology reports · 2016Article
- Epigenetics in Schizophrenia: A Pilot Study of Global DNA Methylation in Different Brain Regions Associated with Higher Cognitive Functions.Frontiers in psychology · 2016Article
- Peripheral biomarkers revisited: integrative profiling of peripheral samples for psychiatric research.Biological psychiatry · 2014Review
- Tsc2 Haploinsufficiency Has Limited Effects on Fetal Brain Cytokine Levels during Gestational Immune Activation.Autism research and treatment · 2014Article
- Maternal immune activation causes age- and region-specific changes in brain cytokines in offspring throughout development.Brain, behavior, and immunity · 2013Article
- Inflammatory cytokines and neurological and neurocognitive alterations in the course of schizophrenia.Biological psychiatry · 2013Review
- An environmental analysis of genes associated with schizophrenia: hypoxia and vascular factors as interacting elements in the neurodevelopmental model.Molecular psychiatry · 2012Review
- Major histocompatibility complex class I proteins in brain development and plasticity.Trends in neurosciences · 2012Review
- Structural, genetic, and functional signatures of disordered neuro-immunological development in autism spectrum disorder.PloS one · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Medical treatment with various cytokines can provoke psychiatric symptoms. Conversely, psychiatric patients can display abnormalities in cytokine and neurotrophic factor expression. Such observations have pointed to the potential contribution of cytokines and growth factors to schizophrenic pathology and/or etiology. The cellular targets of the relevant factors and the nature of their actions remain to be explored in mental illness, however. Recent physiological studies demonstrate that cytokines and neurotrophic factors can markedly influence synaptic transmission and plasticity upon acute or chronic application. Moreover, many of the molecular alterations observed in the schizophrenic brain are consistent with abnormalities in cytokine and neurotrophic factor regulation of these molecules. In this review, we summarize these molecular pathology findings for schizophrenia and highlight the neurodevelopmental activities of cytokines and neurotrophic factors that may contribute to the etiology or pathology of this illness.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.