ArticleOncogene2000
H19 gene expression is up-regulated exclusively by stabilization of the RNA during muscle cell differentiation.
Article in Oncogene, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 56 citations in OpenAlex.
- Exploring the cellular and molecular basis of murine cardiac development through spatiotemporal transcriptome sequencing.GigaScience · 2025Article
- Simultaneous Profiling of Transcripts and Genomic Regions Associated with Nuclear Bodies Using the RNA-DNA High-Salt Recovered Sequence (RD-HRS) Method.Methods in molecular biology (Clifton, N.J.) · 2025Article
- LncRNA 4930581F22Rik promotes myogenic differentiation by regulating the ERK/MAPK signaling pathway.Heliyon · 2024Article
- Long Noncoding RNAs in the Pathogenesis of Insulin Resistance.International journal of molecular sciences · 2022Review
- Article
- H19 inhibition increases HDAC6 and regulates IRS1 levels and insulin signaling in the skeletal muscle during diabetes.Molecular medicine (Cambridge, Mass.) · 2022Article
- Characterization of transcripts emanating from enhancer Eβ of the murine TCRβ locus.FEBS open bio · 2021Article
- Characterization of Long Non-coding RNAs Modified by mFrontiers in cell and developmental biology · 2021Article
- LncRNAH19 improves insulin resistance in skeletal muscle by regulating heterogeneous nuclear ribonucleoprotein A1.Cell communication and signaling : CCS · 2020Article
- High-salt-recovered sequences are associated with the active chromosomal compartment and with large ribonucleoprotein complexes including nuclear bodies.Genome research · 2018Article
- Beyond brown adipogenesis the inheritance of imprinted H19.Non-coding RNA investigation · 2018Article
- Current status and strategies of long noncoding RNA research for diabetic cardiomyopathy.BMC cardiovascular disorders · 2018Review
- The Interplay of LncRNA-H19 and Its Binding Partners in Physiological Process and Gastric Carcinogenesis.International journal of molecular sciences · 2017Review
- The H19 Long non-coding RNA in cancer initiation, progression and metastasis - a proposed unifying theory.Molecular cancer · 2015Review
- miR-CLIP capture of a miRNA targetome uncovers a lincRNA H19-miR-106a interaction.Nature chemical biology · 2015Article
- The H19/let-7 double-negative feedback loop contributes to glucose metabolism in muscle cells.Nucleic acids research · 2014Article
- The imprinted H19 lncRNA antagonizes let-7 microRNAs.Molecular cell · 2013Article
- Expression of the h19 oncofetal gene in premalignant lesions of cervical cancer: a potential targeting approach for development of nonsurgical treatment of high-risk lesions.ISRN obstetrics and gynecology · 2013Article
- Downregulation of H19 improves the differentiation potential of mouse parthenogenetic embryonic stem cells.Stem cells and development · 2012Article
- H19 antisense RNA can up-regulate Igf2 transcription by activation of a novel promoter in mouse myoblasts.PloS one · 2012Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
H19 is a paternally imprinted gene whose expression produces a 2.4 kb RNA in most tissues during development and in mammalian myoblastic cell lines upon differentiation. Deletion of the active maternal allele of H19 and its flanking regions in the mouse leads to biallelic methylation and loss of imprinting of the neighbouring Igf2 gene. The function of H19 RNA remains unknown and, although polysome-associated, the absence of a conserved open reading frame suggests that it does not encode a protein product. We describe a novel post-transcriptional regulation of H19 gene expression which, in spite of this lack of coding capacity, is dependent on translational activity. We show that stabilization of the RNA is solely responsible for its accumulation during in vitro muscle cell differentiation. This conclusion is based on the finding that inhibition of protein synthesis results in a dramatic destabilization of H19 RNA in proliferating mouse C2C12 myoblastic cells but not in differentiated cells, and on run-on experiments which showed that the rate of transcription of H19 RNA remains constant during muscle cell differentiation. This mechanism could also be involved in H19 gene expression during mouse development in addition to its transcriptional activation which we have shown to occur.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.