ArticleOncogene2000
A comparative evaluation of beta-catenin and plakoglobin signaling activity.
Article in Oncogene, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 64 citations in OpenAlex.
- Adipocyte-specific ablation of plakoglobin in mice does not affect adiposity but results in sexual-dimorphic effects on weight gain.Physiological reports · 2025Article
- miR-195-5p as Regulator of γ-Catenin and Desmosome Junctions in Colorectal Cancer.International journal of molecular sciences · 2023Article
- Plakoglobin restores tumor suppressor activity of p53Cancer science · 2018Article
- The canonical way to make a heart: β-catenin and plakoglobin in heart development and remodeling.Experimental biology and medicine (Maywood, N.J.) · 2017Review
- γ-Catenin acts as a tumor suppressor through context-dependent mechanisms in colorectal cancer.International journal of colorectal disease · 2017Article
- Beyond cell-cell adhesion: Plakoglobin and the regulation of tumorigenesis and metastasis.Oncotarget · 2017Review
- Nuclear roles for cilia-associated proteins.Cilia · 2017Review
- Structure-based mutational analysis of ICAT residues mediating negative regulation of β-catenin co-transcriptional activity.PloS one · 2017Article
- Beyond β-catenin: prospects for a larger catenin network in the nucleus.Nature reviews. Molecular cell biology · 2016Review
- Pathogenesis of Arrhythmogenic Cardiomyopathy.The Canadian journal of cardiology · 2015Review
- Nuclear signaling from cadherin adhesion complexes.Current topics in developmental biology · 2015Review
- Implications of targeted genomic disruption of β-catenin in BxPC-3 pancreatic adenocarcinoma cells.PloS one · 2014Article
- γ-Catenin is overexpressed in acute myeloid leukemia and promotes the stabilization and nuclear localization of β-catenin.Leukemia · 2013Article
- Ectopic γ-catenin expression partially mimics the effects of stabilized β-catenin on embryonic stem cell differentiation.PloS one · 2013Article
- Beyond cell adhesion: the role of armadillo proteins in the heart.Cellular signalling · 2013Review
- Plakoglobin: role in tumorigenesis and metastasis.International journal of cell biology · 2012Article
- Differential requirement for the dual functions of β-catenin in embryonic stem cell self-renewal and germ layer formation.Nature cell biology · 2011Article
- Cell-cell contact preserves cell viability via plakoglobin.PloS one · 2011Article
- γ-Catenin is an independent prognostic marker in early stage colorectal cancer.International journal of colorectal disease · 2010Article
- Junctional music that the nucleus hears: cell-cell contact signaling and the modulation of gene activity.Cold Spring Harbor perspectives in biology · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 1 country.
Funding
Abstract
Vertebrates have two Armadillo-like proteins, beta-catenin and plakoglobin. Mutant forms of beta-catenin with oncogenic activity are found in many human tumors, but plakoglobin mutations are not commonly found. In fact, plakoglobin has been proposed to suppress tumorigenesis. To assess differences between beta-catenin and plakoglobin, we compared several of their biochemical properties. After transient transfection of 293T cells with an expression vector encoding either of the two proteins, soluble wild type beta-catenin does not significantly accumulate, whereas soluble wild type plakoglobin is readily detected. As anticipated, beta-catenin is stabilized by the oncogenic mutation S37A; however, the analogous mutation in plakoglobin (S28A) does not alter its half-life. S37A-beta-catenin activates a TCF/LEF-dependent reporter 20-fold more potently than wild type beta-catenin, and approximately 5-fold more potently than wild type or S28A plakoglobin. These differences may be attributable to an enhanced affinity of S37A beta-catenin for LEF1 and TCF4, as observed here by immunoprecipitation assays. We show that the carboxyl-terminal domain is largely responsible for the difference in signaling and that the Armadillo repeats account for the remainder of the difference. The relatively weak signaling by plakoglobin and the failure of the S28A mutation to enhance its stability, may explain why plakoglobin mutations are infrequent in malignancies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.