ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2000
Inhibitory mechanism by polysialic acid for lamina-specific branch formation of thalamocortical axons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 63 citations in OpenAlex.
- Direct and Indirect Downstream Pathways That Regulate Repulsive Guidance Effects of FGF3 on Developing Thalamocortical Axons.International journal of molecular sciences · 2025Article
- Review
- Visualization of Thalamocortical Axon Branching and Synapse Formation in Organotypic Cocultures.Journal of visualized experiments : JoVE · 2018Article
- Nucleocytoplasmic Shuttling of Histone Deacetylase 9 Controls Activity-Dependent Thalamocortical Axon Branching.Scientific reports · 2017Article
- Netrin-4 regulates thalamocortical axon branching in an activity-dependent fashion.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Phosphoinositide pathway and the signal transduction network in neural development.Neuroscience bulletin · 2012Review
- The effect of PTZ-induced epileptic seizures on hippocampal expression of PSA-NCAM in offspring born to kindled rats.Journal of biomedical science · 2012Article
- Termination and initial branch formation of SNAP-25-deficient thalamocortical fibres in heterochronic organotypic co-cultures.The European journal of neuroscience · 2012Article
- Neural cell adhesion molecule, NCAM, regulates thalamocortical axon pathfinding and the organization of the cortical somatosensory representation in mouse.Frontiers in molecular neuroscience · 2012Article
- Thalamocortical pathfinding defects precede degeneration of the reticular thalamic nucleus in polysialic acid-deficient mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Article
- Role of pre- and postsynaptic activity in thalamocortical axon branching.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Interplay between laminar specificity and activity-dependent mechanisms of thalamocortical axon branching.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Polysialylated neural cell adhesion molecule is involved in induction of long-term potentiation and memory acquisition and consolidation in a fear-conditioning paradigm.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Polysialic acid-induced plasticity reduces neuropathic insult to the central nervous system.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Activity dependence of cortical axon branch formation: a morphological and electrophysiological study using organotypic slice cultures.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- N-cadherin regulates ingrowth and laminar targeting of thalamocortical axons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During development, thalamocortical axons form arbors primarily in layer 4 of the neocortex. This lamina-specific branch formation was studied in cultures of rat thalamic explants grown next to chemically fixed cortical slices. After a week in vitro, thalamic axons formed branches specifically in the target layer of fixed cortical slices, regardless of the orientation of the ingrowth. This in vitro system permits a direct assessment of contributions of membrane-associated molecules to thalamic axon branch formation. To this end, the present study uses three enzymatic perturbations: chondroitinase, phosphatidylinositol phospholipase C, or the polysialic acid (PSA)-specific endoneuraminidase (endo N). With endo N pretreatment of cortex, the number of branch points was increased significantly, whereas branch tip length was decreased. In addition, the localization of branch points to the target layer was weakened considerably. These features of branch formation were not altered by the other two enzymatic treatments, except that branch tips were shortened by chondroitinase treatment to the same extent as in endo N treatment. These results suggest that membrane-bound components are involved in lamina-specific branch formation of thalamocortical axons, and in particular that PSA moieties contribute to laminar specificity by inhibiting branch emergence in inappropriate layers.
Indexed as
Identifiers
11124992PMC6773036W1551345712What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.