ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2000
Agrin controls synaptic differentiation in hippocampal neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
38 citing papers in PubMed, 90 citations in OpenAlex.
- Heparan Sulfate Proteoglycans: Master Regulators of Cellular Signaling, Tissue Development, and Neural Function.Journal of neuroscience research · 2026Review
- Optogenetic and Endogenous Modulation of CaInternational journal of molecular sciences · 2025Review
- Optimal Extracellular Matrix Niches for Neurogenesis: Identifying Glycosaminoglycan Chain Composition in the Subventricular Neurogenic Zone.Frontiers in neuroanatomy · 2021Review
- Extracellular vesicles from human iPSC-derived neural stem cells: miRNA and protein signatures, and anti-inflammatory and neurogenic properties.Journal of extracellular vesicles · 2020Article
- Synaptogenesis Is Modulated by Heparan Sulfate inGenetics · 2018Article
- Diverse roles for glycosaminoglycans in neural patterning.Developmental dynamics : an official publication of the American Association of Anatomists · 2018Review
- Tumor suppressor menin is required for subunit-specific nAChR α5 transcription and nAChR-dependent presynaptic facilitation in cultured mouse hippocampal neurons.Scientific reports · 2017Article
- Two proteolytic fragments of menin coordinate the nuclear transcription and postsynaptic clustering of neurotransmitter receptors during synaptogenesis between Lymnaea neurons.Scientific reports · 2016Article
- Scale Invariant Disordered Nanotopography Promotes Hippocampal Neuron Development and Maturation with Involvement of Mechanotransductive Pathways.Frontiers in cellular neuroscience · 2016Article
- Heparan sulfate proteoglycans: a sugar code for vertebrate development?Development (Cambridge, England) · 2015Review
- Extracellular matrix control of dendritic spine and synapse structure and plasticity in adulthood.Frontiers in neuroanatomy · 2014Review
- The role of agrin in synaptic development, plasticity and signaling in the central nervous system.Neurochemistry international · 2012Review
- Agrin-signaling is necessary for the integration of newly generated neurons in the adult olfactory bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Casting a net on dendritic spines: the extracellular matrix and its receptors.Developmental neurobiology · 2011Review
- Secreted factors as synaptic organizers.The European journal of neuroscience · 2010Review
- The process-inducing activity of transmembrane agrin requires follistatin-like domains.The Journal of biological chemistry · 2010Article
- Collagen XIX is expressed by interneurons and contributes to the formation of hippocampal synapses.The Journal of comparative neurology · 2010Article
- Transmembrane agrin regulates dendritic filopodia and synapse formation in mature hippocampal neuron cultures.Neuroscience · 2009Article
- Transmembrane form agrin-induced process formation requires lipid rafts and the activation of Fyn and MAPK.The Journal of biological chemistry · 2009Article
- Binding of laminin-1 to monosialoganglioside GM1 in lipid rafts is crucial for neurite outgrowth.Journal of cell science · 2009Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Agrin controls the formation of the neuromuscular junction. Whether it regulates the differentiation of other types of synapses remains unclear. Therefore, we have studied the role of agrin in cultured hippocampal neurons. Synaptogenesis was severely compromised when agrin expression or function was suppressed by antisense oligonucleotides and specific antibodies. The effects of antisense oligonucleotides were found to be highly specific because they were reversed by adding recombinant agrin and could not be detected in cultures from agrin-deficient animals. Interestingly, the few synapses formed in reduced agrin conditions displayed diminished vesicular turnover, despite a normal appearance at the EM level. Thus, our results demonstrate the necessity of agrin for synaptogenesis in hippocampal neurons.
Indexed as
Identifiers
11124985PMC6773041W1945344069What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.