ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2000
Water permeability of cochlear outer hair cells: characterization and relationship to electromotility.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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Who cites it
19 citing papers in PubMed, 50 citations in OpenAlex.
- Advancements in prevention and intervention of sensorineural hearing loss.Therapeutic advances in chronic disease · 2022Review
- Cooperativity of KScience advances · 2020Article
- A model of ionic transport and osmotic volume control in cochlear outer hair cells.Interface focus · 2014Article
- Prestin regulation and function in residual outer hair cells after noise-induced hearing loss.PloS one · 2013Article
- Osmotic properties of auditory hair cells in the leopard frog: evidence for water-permeable channels.Hearing research · 2011Article
- Changes in plasma membrane structure and electromotile properties in prestin deficient outer hair cells.Cytoskeleton (Hoboken, N.J.) · 2010Article
- Compartmentalization of the outer hair cell demonstrated by slow diffusion in the extracisternal space.Biophysical journal · 2009Article
- Functional prestin transduction of immature outer hair cells from normal and prestin-null mice.Journal of the Association for Research in Otolaryngology : JARO · 2008Article
- A combined patch-clamp and electrorotation study of the voltage- and frequency-dependent membrane capacitance caused by structurally dissimilar lipophilic anions.The Journal of membrane biology · 2008Article
- Lateral wall protein content mediates alterations in cochlear outer hair cell mechanics before and after hearing onset.Cell motility and the cytoskeleton · 2007Article
- Hypotonic swelling of salicylate-treated cochlear outer hair cells.Hearing research · 2007Article
- Regulation of electromotility in the cochlear outer hair cell.The Journal of physiology · 2006Review
- On the effect of prestin on the electrical breakdown of cell membranes.Biophysical journal · 2006Article
- Extraction of prestin-dependent and prestin-independent components from complex motile responses in guinea pig outer hair cells.Biophysical journal · 2005Article
- Sugar transport by mammalian members of the SLC26 superfamily of anion-bicarbonate exchangers.The Journal of physiology · 2003Article
- Expression of aquaporin 1 and 5 in the developing mouse inner ear and audiovestibular assessment of an Aqp5 null mutant.Journal of the Association for Research in Otolaryngology : JARO · 2003Article
- Cl- flux through a non-selective, stretch-sensitive conductance influences the outer hair cell motor of the guinea-pig.The Journal of physiology · 2003Article
- Electromechanical models of the outer hair cell composite membrane.The Journal of membrane biologyReview
- Tuning in to the amazing outer hair cell: membrane wizardry with a twist and shout.The Journal of membrane biologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
The distinguishing feature of the mammalian outer hair cells (OHCs) is to elongate and shorten at acoustic frequencies, when their intracellular potential is changed. This "electromotility" or "electromechanics" depends critically on positive intracellular pressure (turgor), maintained by the inflow of water through yet uncharacterized water pathways. We measured the water volume flow, J(v), across the plasma membrane of isolated guinea pig and rat OHCs after osmotic challenges and estimated the osmotic water permeability coefficient, P(f), to be approximately 10(-2) cm/sec. This value is within the range reported for osmotic flow mediated by the water channel proteins, aquaporins. J(v) was inhibited by HgCl(2), which is known to block aquaporin-mediated water transport. P(f) values that were estimated for OHCs from neonatal rats were of the order of approximately 2 x 10(-3) cm/sec, equivalent to that of membranes lacking water channel proteins. In an immunofluorescence assay we showed that an anti-peptide antibody specific for aquaporins labels the lateral plasma membrane of the OHC in the region in which electromotility is generated. Using patch-clamp recording, we found that water influx into the OHC is regulated by intracellular voltage. We also found that the most pronounced increases of the electromotility-associated charge movement and of the expression of OHC water channels occur between postnatal days 8 and 12, preceding the onset of hearing function in the rat. Our data indicate that electromotility and water transport in OHCs may influence each other structurally and functionally.
Indexed as
Identifiers
11124975PMC6773017W2129666601What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.