ArticleArchives of disease in childhood2001
Use of acetazolamide to decrease cerebrospinal fluid production in chronically ventilated patients with ventriculopleural shunts.
Article in Archives of disease in childhood, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 101 citations in OpenAlex.
- The Role of Choroid Plexus in Hydrocephalus from the Perspective of Structure and Function: a Therapeutic Target.Molecular neurobiology · 2025Review
- Orthopedic Manifestations of Syringomyelia: A Comprehensive Review.Journal of clinical medicine · 2025Review
- The NaAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Advancing Hydrocephalus Management: Pathogenesis Insights, Therapeutic Innovations, and Emerging Challenges.Aging and disease · 2024Review
- Relaxation-exchange magnetic resonance imaging (REXI): a non-invasive imaging method for evaluating trans-barrier water exchange in the choroid plexus.Fluids and barriers of the CNS · 2024Article
- Sterile Cerebrospinal Fluid Ascites With High Serum Ascites Albumin Gradient Treated With Acetazolamide.ACG case reports journal · 2024Article
- Surgical management of primary and idiopathic internal hydrocephalus in dogs and cats.Frontiers in veterinary science · 2024Review
- Mechanisms of cerebrospinal fluid and brain interstitial fluid production.Neurobiology of disease · 2023Review
- Acetazolamide modulates intracranial pressure directly by its action on the cerebrospinal fluid secretion apparatus.Fluids and barriers of the CNS · 2022Article
- Acetazolamide to treat symptomatic ruptured arachnoid cysts: illustrative cases.Journal of neurosurgery. Case lessons · 2022Article
- Glymphatic System and Subsidiary Pathways Drive Nanoparticles Away from the Brain.Research (Washington, D.C.) · 2022Article
- Bilateral hyperplasia of choroid plexus with severe CSF production: a case report and review of the glymphatic system.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021Article
- IntraOmmaya compartmental radioimmunotherapy usingEuropean journal of nuclear medicine and molecular imaging · 2021Article
- The ventriculo-cholecystic shunt: does CSF volume matter?Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2019Article
- Brain Edema Formation and Functional Outcome After Surgical Decompression in Murine Closed Head Injury Are Modulated by Acetazolamide Administration.Frontiers in neurology · 2019Article
- Cerebrospinal Fluid Shunting Complications in Children.Pediatric neurosurgery · 2017Review
- Trauma of the midface.GMS current topics in otorhinolaryngology, head and neck surgery · 2015Review
- The value of transcranial Doppler imaging in children with tuberculous meningitis.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2014Article
- Novel application of acetazolamide to reduce cerebrospinal fluid production in patients undergoing thoracoabdominal aortic surgery.Interactive cardiovascular and thoracic surgery · 2014Article
- Gene expression and functional annotation of the human and mouse choroid plexus epithelium.PloS one · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acetazolamide (ACTZ), a carbonic anhydrase inhibitor, has been shown to decrease cerebrospinal fluid (CSF) production in both in vivo and in vitro animal models. We report two children with hydrocephalus who experienced multiple shunt failures, and who had externalised ventriculostomy drains (EVD) prior to ventriculopleural shunt placement. The effects of increasing doses of ACTZ on CSF production and subsequent tolerance to ventriculopleural shunts were evaluated. The patients had a 48% and a 39% decrease in their EVD CSF output when compared to baseline with maximum ACTZ dose of 75 mg/kg/day and 50 mg/kg/day, respectively (p < 0.05). This is the first report of change in CSF volume in children after extended treatment with ACTZ. ACTZ treatment in mechanically ventilated paediatric patients with hydrocephalus may improve tolerance of ventriculopleural shunts and minimise respiratory compromise. Potassium and bicarbonate supplements are required to correct metabolic disturbances.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.