ArticlePostgraduate medical journal2001
The clinical impact of metabolic bone disease in coeliac disease.
Article in Postgraduate medical journal, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 89 citations in OpenAlex.
- ACG clinical guidelines: diagnosis and management of celiac disease.The American journal of gastroenterology · 2013Guideline
- Osteoporosis and Osteoporotic Fractures in Gastrointestinal Disease.Journal of bone metabolism · 2018Review
- Celiac disease and risk of fracture in adults--a review.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014Review
- Persistent mucosal damage and risk of fracture in celiac disease.The Journal of clinical endocrinology and metabolism · 2014Article
- Bone mass and mineral metabolism alterations in adult celiac disease: pathophysiology and clinical approach.Nutrients · 2013Review
- Celiac disease is not increased in women with hip fractures and low vitamin D levels.The journal of nutrition, health & aging · 2013Article
- Evaluation and management of skeletal health in celiac disease: position statement.Canadian journal of gastroenterology = Journal canadien de gastroenterologie · 2012Review
- Celiac disease: A missed cause of metabolic bone disease.Indian journal of endocrinology and metabolism · 2012Article
- Osteomalacia associated with cutaneous psoriasis as the presenting feature of coeliac disease: a case report.The Pan African medical journal · 2012Article
- Bone mineral densitometry findings of children with newly diagnosed celiac disease.Molecular imaging and radionuclide therapy · 2011Article
- Risk of fracture in celiac disease: gender, dietary compliance, or both?World journal of gastroenterology · 2011Article
- Screening for celiac disease in a North American population: sequential serology and gastrointestinal symptoms.The American journal of gastroenterology · 2011Article
- Morbidity and mortality among older individuals with undiagnosed celiac disease.Gastroenterology · 2010Article
- A case of variegate porphyria in association with coeliac disease and bisphosphonate associated dental osteonecrosis.Journal of clinical medicine research · 2009Article
- Bone in celiac disease.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2008Review
- Long-term fracture risk in patients with celiac disease: a population-based study in Olmsted County, Minnesota.Digestive diseases and sciences · 2008Article
- Celiac disease: pathophysiology, clinical manifestations, and associated autoimmune conditions.Advances in pediatrics · 2008Review
- Long-term follow-up of individuals with celiac disease: an evaluation of current practice guidelines.Canadian journal of gastroenterology = Journal canadien de gastroenterologie · 2007Review
- Complications of coeliac disease: are all patients at risk?Postgraduate medical journal · 2006Review
- Recent advances in coeliac disease.Gut · 2006Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bone mineral density was measured by dual energy x ray absorptiometry (DEXA) at the lumbar spine and femoral neck in 15 adults who had metabolic bone disease in association with coeliac disease (mean age at diagnosis 53.5 years, range 37 to 66). Results were expressed as a T score (the number of standard deviations by which patient's bone density differed from the sex matched young adult mean). Three patients had no skeletal symptoms and normal routine calcium biochemistry but severely reduced axial bone mineral density on DEXA. Eleven patients had symptomatic skeletal fractures, including fractures of proximal femur (3), vertebrae (4), and radius (6). Three patients had osteomalacia confirmed on bone biopsy, two of whom had characteristic biochemistry. Secondary and tertiary hyperparathyroidism were seen. Seventy five further patients (60 female) with coeliac disease (mean age 52.0 years, median duration of gluten-free diet 3.4 years) and 75 paired healthy age and sex matched controls were questioned on past fracture history. Patients with coeliac disease underwent detailed studies of calcium biochemistry, dietary intake, and bone mineral density. Sixteen had a past history of fractures (chi(2) = 10.7, p = 0.0004, v controls), which were of typical osteoporotic type. Ten patients had fracture before diagnosis of coeliac disease and six after diagnosis. Patients who had a fracture were older (56.3 v 50.3 years, p < 0.02, Wilcoxon rank sum test) than those with no fracture. There was no significant difference in bone mineral density (z score -0.31 v -0. 77), serum calcium (2.30 v 2.26 mmol/l), 25-hydroxyvitamin D (19.7 v 23.7 nmol/l), parathyroid hormone (2.6 v 3.1 pmol/l), or dietary calcium intake (1021.0 v 1033.0 mg/day) in patients with fracture compared with those without fracture. Metabolic bone disease is common in coeliac disease and is associated with premature osteoporotic fractures.
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