ReviewCurrent rheumatology reports1999
Integrin signaling in fibrosis and scleroderma.
Review in Current rheumatology reports, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 23 citations in OpenAlex.
- CW-EPR studies revealed different motional properties and oligomeric states of the integrin β1a transmembrane domain in detergent micelles or liposomes.Scientific reports · 2015Article
- Integrins as Therapeutic Targets for Respiratory Diseases.Current molecular medicine · 2015Review
- Integrin α1 has a long helix, extending from the transmembrane region to the cytoplasmic tail in detergent micelles.PloS one · 2013Article
- MicroRNA array analysis of microRNAs related to systemic scleroderma.Rheumatology international · 2012Article
- Article
- Inhibition of ERK promotes collagen gel compaction and fibrillogenesis to amplify the osteogenesis of human mesenchymal stem cells in three-dimensional collagen I culture.Stem cells and development · 2009Article
- Cross-talk between integrins alpha1beta1 and alpha2beta1 in renal epithelial cells.Experimental cell research · 2008Article
- Osteogenic differentiation of mesenchymal stem cells in defined protein beads.Journal of biomedical materials research. Part B, Applied biomaterials · 2008Article
- Elevated matrix metalloprotease and angiostatin levels in integrin alpha 1 knockout mice cause reduced tumor vascularization.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Integrins are a large family of heterodimeric transmembrane receptors for extracellular matrix proteins. As well as mediating cell attachment and the bulk of force transduction from the cytoskeleton, they convey signals from the extracellular matrix to the cell. alpha1beta1 and alpha2beta1 are the major collagen receptors in this family. a1beta1 provides negative feedback on collagen synthesis, whereas alpha2beta1 stimulates the synthesis of matrix metalloproteases. Each receptor modulates the signaling activity of the other to coordinate matrix synthesis and remodeling. Expression of both is reduced in scleroderma despite a paracrine environment which would be expected to upregulate them. Deficiencies in the integrins correlate with upregulated collagen synthesis and downregulated metalloprotease synthesis seen during the disease.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.