ReviewCurrent oncology reports2000
Gene therapy for brain tumors.
Review in Current oncology reports, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 39 citations in OpenAlex.
- Viral Gene Therapy for Glioblastoma Multiforme: A Promising Hope for the Current Dilemma.Frontiers in oncology · 2021Review
- Gene therapies for high-grade gliomas: from the bench to the bedside.Acta bio-medica : Atenei Parmensis · 2020Review
- Glioblastoma Treatment Modalities besides Surgery.Journal of Cancer · 2019Review
- Antitumor activity of combined endostatin and thymidine kinase gene therapy in C6 glioma models.Cancer medicine · 2016Article
- Current status of intratumoral therapy for glioblastoma.Journal of neuro-oncology · 2015Article
- Gene therapy for malignant glioma.Molecular and cellular therapies · 2014Review
- The art of gene therapy for glioma: a review of the challenging road to the bedside.Journal of neurology, neurosurgery, and psychiatry · 2013Review
- Oncolytic virotherapy for malignant glioma: translating laboratory insights into clinical practice.Frontiers in oncology · 2013Article
- Fatty acid synthase: a novel target for antiglioma therapy.British journal of cancer · 2006Article
- Replicating retroviral vectors mediating continuous production and secretion of therapeutic gene products from cancer cells.Cancer gene therapy · 2005Article
- Nonneurotropic adenovirus: a vector for gene transfer to the brain and gene therapy of neurological disorders.International review of neurobiology · 2003Review
- Gene Therapy for Pediatric Cancer: State of the Art and Future Perspectives.Journal of biomedicine & biotechnology · 2003Article
- Gene therapy for glioblastoma: future perspective for delivery systems and molecular targets.Cellular and molecular neurobiology · 2001Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
"Gene therapy" can be defined as the transfer of genetic material into a patient's cells for therapeutic purposes. To date, a diverse and creative assortment of treatment strategies utilizing gene therapy have been devised, including gene transfer for modulating the immune system, enzyme prodrug ("suicide gene") therapy, oncolytic therapy, replacement/therapeutic gene transfer, and antisense therapy. For malignant glioma, gene-directed prodrug therapy using the herpes simplex virus thymidine kinase gene was the first gene therapy attempted clinically. A variety of different strategies have now been pursued experimentally and in clinical trials. Although, to date, gene therapy for brain tumors has been found to be reasonably safe, concerns still exist regarding issues related to viral delivery, transduction efficiency, potential pathologic response of the brain, and treatment efficacy. Improved viral vectors are being sought, and potential use of gene therapy in combination with other treatments is being investigated.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.