ReviewCurrent atherosclerosis reports2000
Niacin dosing: relationship to benefits and adverse effects.
Review in Current atherosclerosis reports, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 87 citations in OpenAlex.
- Measuring flushing symptoms with extended-release niacin using the flushing symptom questionnaire: results from a randomised placebo-controlled clinical trial.International journal of clinical practice · 2008Trial
- Review
- Niacin and Stroke: The Role of Supplementation and Emerging Concepts in Clinical Practice, a Narrative Review.Current issues in molecular biology · 2025Review
- Article
- Current Understanding on the Role of Lipids in Macrophages and Associated Diseases.International journal of molecular sciences · 2022Review
- The effects of nicotinamide adenine dinucleotide in cardiovascular diseases: Molecular mechanisms, roles and therapeutic potential.Genes & diseases · 2022Review
- Determination of niacin profiles in some animal and plant based foods by high performance liquid chromatography: association with healthy nutrition.Journal of animal science and technology · 2019Article
- Nutritional properties of the largest bamboo fruit Melocanna baccifera and its ecological significance.Scientific reports · 2016Article
- The role of lipids in the pathogenesis and treatment of type 2 diabetes and associated co-morbidities.BMB reports · 2016Review
- TRPV1 channels are involved in niacin-induced cutaneous vasodilation in mice.Journal of cardiovascular pharmacology · 2015Article
- Ocular Effects of Niacin: A Review of the Literature.Medical hypothesis, discovery & innovation ophthalmology journal · 2015Review
- Crosstalk between poly(ADP-ribose) polymerase and sirtuin enzymes.Molecular aspects of medicine · 2013Review
- Cystoid macular edema induced by low doses of nicotinic Acid.Case reports in ophthalmological medicine · 2013Article
- Regulation and deregulation of cholesterol homeostasis: The liver as a metabolic "power station".World journal of hepatology · 2012Article
- Acute effects of a thermogenic nutritional supplement on cycling time to exhaustion and muscular strength in college-aged men.Journal of the International Society of Sports Nutrition · 2009Article
- Combined effects of niacin and chromium treatment on vascular endothelial dysfunction in hyperlipidemic rats.Molecular biology reports · 2009Article
- The effects of combined treatment with niacin and chromium on the renal tissues of hyperlipidemic rats.Molecular and cellular biochemistry · 2007Article
- Management of dyslipidemia in women in the post-hormone therapy era.Journal of general internal medicine · 2005Review
- Pathophysiology and treatment of the dyslipidemia of insulin resistance.Current cardiology reports · 2001Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Because of the original observation by Altschul et al., that nicotinic acid (niacin), not nicotinamide, in pharmacologic doses lowered human serum cholesterol levels, an avalanche of reports have been published over the past 45 years on the plasma lipid-regulating properties of this drug and its beneficial cardiovascular effects. A myriad of studies that have examined efficacy, safety, adverse effects, and pharmacologic properties of niacin rendered convincing evidence that niacin, used alone or combined with other agents, has favorable effects on serum lipoprotein regulation and on containment of atherothrombotic cardiovascular diseases. However, because of the unusual side effect profile of niacin and the availability of various formulations of this drug, niacin must be used prudently and with careful instruction and monitoring of patients. This review summarizes the pertinent and recent literature on niacin that impacts its therapeutic use. We also discuss some controversial issues and personal clinical experience and opinions on this topic.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.