ReviewCurrent atherosclerosis reports1999
Common mutations of the lipoprotein lipase gene and their clinical significance.
Review in Current atherosclerosis reports, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 50 citations in OpenAlex.
- Article
- Germline variant analysis from a cohort of patients with severe hypertriglyceridemia in Brazil.Molecular genetics and metabolism reports · 2024Article
- Review
- Current Data and New Insights into the Genetic Factors of Atherogenic Dyslipidemia Associated with Metabolic Syndrome.Diagnostics (Basel, Switzerland) · 2023Review
- Genome-wide expression reveals potential biomarkers in breast cancer bone metastasis.Journal of integrative bioinformatics · 2022Article
- Etiologic Puzzle of Coronary Artery Disease: How Important Is Genetic Component?Life (Basel, Switzerland) · 2022Review
- Case Report: Genetic Analysis of PEG-Asparaginase Induced Severe Hypertriglyceridemia in an Adult With Acute Lymphoblastic Leukaemia.Frontiers in genetics · 2022Article
- Genetic association ofCardiovascular endocrinology & metabolism · 2021Article
- Gualou Xiebai Banxia decoction ameliorates Poloxamer 407-induced hyperlipidemia.Bioscience reports · 2021Article
- Association of Metabolic Syndrome with Aerobic Exercise and LPL rs3779788 Polymorphism in Taiwan Biobank Individuals.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Article
- Advances in Research on the Bioactivity of Alginate Oligosaccharides.Marine drugs · 2020Review
- Intravascular triglyceride lipolysis becomes crystal clear.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Rare LPL gene missense mutation in an infant with hypertriglyceridemia.Journal of clinical laboratory analysis · 2018Article
- Lipoprotein lipase as a candidate target for cancer prevention/therapy.Biochemistry research international · 2012Article
- Concurrent suppression of hyperlipidemia and intestinal polyp formation by NO-1886, increasing lipoprotein lipase activity in Min mice.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Severe hypertriglyceridaemia in a Greek infant: a clinical, biochemical and genetic study.European journal of pediatrics · 2004Article
- Apolipoprotein AV gene polymorphisms (T-1131/C and Ser19/Trp) influence plasma triglyceride levels and risk of myocardial infarction.Experimental and clinical cardiology · 2003Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The accumulation of triglyceride-rich lipoproteins is an independent factor for an increased risk for premature arteriosclerosis. Common mutations in the lipoprotein lipase (LPL) gene are at least in part inherited susceptibility factors involved in the age- and sex-dependent phenotypic expression of hypertriglyceridemia. It can be estimated that about 20% of patients with hypertriglyceridemia are carriers of common LPL gene mutations (Asp9Asn, Asn291Ser, Trp86Arg, Gly188Glu, Pro207Leu, Asp250Asn) associated with the HLP. Genotyping of these LPL gene mutations is recommended especially in patients with high risk for premature arteriosclerosis. A comparably high number of individuals are carriers of common mutations (Ser447X) or silent mutations (Thr361) associated with low favorable lipids.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.