ArticleImmunology2000
A critical role for alveolar macrophages in elicitation of pulmonary immune fibrosis.
Article in Immunology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 43 citations in OpenAlex.
- Novel strategy of combined interstitial macrophage depletion with intravenous targeted therapy to ameliorate pulmonary fibrosis.Materials today. Bio · 2023Article
- Myeloid cell-specific deletion of Capns1 prevents macrophage polarization toward the M1 phenotype and reduces interstitial lung disease in the bleomycin model of systemic sclerosis.Arthritis research & therapy · 2022Article
- Anti-inflammatory and vasculogenic conditioning of peripheral blood mononuclear cells reinforces their therapeutic potential for radiation-injured salivary glands.Stem cell research & therapy · 2019Article
- The class D scavenger receptor CD68 contributes to mouse chronic liver injury.Immunologic research · 2018Article
- Pathophysiology and classification of primary graft dysfunction after lung transplantation.Journal of thoracic disease · 2017Review
- Loss of CD73 prevents accumulation of alternatively activated macrophages and the formation of prefibrotic macrophage clusters in irradiated lungs.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2017Article
- Triptolide mitigates radiation-induced pulmonary fibrosis via inhibition of axis of alveolar macrophages-NOXes-ROS-myofibroblasts.Cancer biology & therapy · 2016Article
- A pneumocyte-macrophage paracrine lipid axis drives the lung toward fibrosis.American journal of respiratory cell and molecular biology · 2015Article
- Association of age-dependent liver injury and fibrosis with immune cell populations.Liver international : official journal of the International Association for the Study of the Liver · 2013Article
- In vivo targeting of alveolar macrophages via RAFT-based glycopolymers.Biomaterials · 2012Article
- Alveolar macrophages play a key role in cockroach-induced allergic inflammation via TNF-α pathway.PloS one · 2012Article
- Studying the mononuclear phagocyte system in the molecular age.Nature reviews. Immunology · 2011Review
- Kupffer cells influence parenchymal invasion and phenotypic orientation, but not the proliferation, of liver progenitor cells in a murine model of liver injury.The American journal of pathology · 2011Article
- The chemokine, CCL3, and its receptor, CCR1, mediate thoracic radiation-induced pulmonary fibrosis.American journal of respiratory cell and molecular biology · 2011Article
- Tgf-Beta isoform specific regulation of airway inflammation and remodelling in a murine model of asthma.PloS one · 2010Article
- Abnormal lymphangiogenesis in idiopathic pulmonary fibrosis with insights into cellular and molecular mechanisms.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Macrophages produce TGF-beta-induced (beta-ig-h3) following ingestion of apoptotic cells and regulate MMP14 levels and collagen turnover in fibroblasts.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Pegylated interferon-alpha plus taurine in treatment of rat liver fibrosis.World journal of gastroenterology · 2007Article
- Impairment of alveolar macrophage transcription in idiopathic pulmonary fibrosis.American journal of respiratory and critical care medicine · 2007Article
- Effects of alveolar macrophage depletion on liposomal vaccine protection against respiratory syncytial virus (RSV).Clinical and experimental immunology · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hapten immune pulmonary interstitial fibrosis (HIPIF) is induced by a recall cell-mediated immune response against the hapten 2,4, 6-trinitrobenzene sulphonic acid (TNBS) in the lung. Studies here dissect the role of the cellular components of the bronchoalveolar lavage (BAL) cells (alveolar macrophages [AMs] versus monocytes and immature dendritic cells) in the fibrogenic inflammatory response. BAL cells from HIPIF mice were generally more activated and produced a greater amount of tumour necrosis factor-alpha (TNF-alpha) than controls. Liposome-encapsulated dichloromethylene diphosphonate (Cl(2)MDP) that was inoculated intranasally (i.n.) into mice selectively depleted AMs. Following AM depletion, the number of TNF-alpha-containing cells was reduced, and both the number of immune inflammatory cells recruited into the alveolar space and the subsequent collagen deposition (hydroxyproline) were decreased in the sensitized and intratracheally (i.t.) challenged mice. In conclusion, AMs are required, in part, for the development of pulmonary fibrosis in HIPIF because AM-derived factors such as TNF-alpha are needed for initiation of chemokine and cytokine pathways and accumulation of immune inflammatory cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.