ArticleClinical and experimental immunology2000
Gram-negative bacteria induce proinflammatory cytokine production by monocytes in the absence of lipopolysaccharide (LPS).
Article in Clinical and experimental immunology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 50 citations in OpenAlex.
- Establishing an invertebrateVirulence · 2021Article
- The reproductive cycle is a pathogenic determinant during gonococcal pelvic inflammatory disease in mice.Mucosal immunology · 2016Article
- Recognition of Neisseria meningitidis by the long pentraxin PTX3 and its role as an endogenous adjuvant.PloS one · 2015Article
- Identification of genes particularly sensitive to lipopolysaccharide (LPS) in human monocytes induced by wild-type versus LPS-deficient Neisseria meningitidis strains.Infection and immunity · 2008Article
- Comparison of the inflammatory responses of human meningeal cells following challenge with Neisseria lactamica and with Neisseria meningitidis.Infection and immunity · 2006Article
- Differential role of lipooligosaccharide of Neisseria meningitidis in virulence and inflammatory response during respiratory infection in mice.Infection and immunity · 2006Article
- MyD88-dependent signaling affects the development of meningococcal sepsis by nonlipooligosaccharide ligands.Infection and immunity · 2006Article
- Complement activation and complement-dependent inflammation by Neisseria meningitidis are independent of lipopolysaccharide.Infection and immunity · 2004Article
- High-level endothelial E-selectin (CD62E) cell adhesion molecule expression by a lipopolysaccharide-deficient strain of Neisseria meningitidis despite poor activation of NF-kappaB transcription factor.Clinical and experimental immunology · 2004Article
- Activation of human dendritic cells is modulated by components of the outer membranes of Neisseria meningitidis.Infection and immunity · 2003Article
- Lipooligosaccharide-deficient Neisseria meningitidis shows altered pilus-associated characteristics.Infection and immunity · 2003Article
- Characterization of humoral and cellular immune responses elicited by meningococcal carriage.Infection and immunity · 2002Article
- Meningococcal bacterial DNA load at presentation correlates with disease severity.Archives of disease in childhood · 2002Article
- Interaction of Neisseria meningitidis with human dendritic cells.Infection and immunity · 2001Article
- Dendritic cell activation and cytokine production induced by group B Neisseria meningitidis: interleukin-12 production depends on lipopolysaccharide expression in intact bacteria.Infection and immunity · 2001Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tumour necrosis factor-alpha (TNF-alpha), IL-1alpha and IL-6 production by human monocytes in response to a clinical strain of the Gram-negative encapsulated bacteria Neisseria meningitidis and an isogenic lpxA- strain deficient in LPS was investigated. Wild-type N. meningitidis at concentrations between 105 and 108 organisms/ml and purified LPS induced proinflammatory cytokine production. High levels of these cytokines were also produced in response to the lpxA- strain at 107 and 108 organisms/ml. The specific LPS antagonist bactericidal/permeability-increasing protein (rBPI21) inhibited cytokine production induced by LPS and wild-type bacteria at 105 organisms/ml but not at higher concentrations, and not by LPS-deficient bacteria at any concentration. These data show that proinflammatory cytokine production by monocytes in response to N. meningitidis does not require the presence of LPS. Therapeutic strategies designed to block LPS alone may not therefore be sufficient for interrupting the inflammatory response in severe meningococcal disease.
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