ArticleNucleic acids research2000
Comparison of the Escherichia coli K-12 genome with sampled genomes of a Klebsiella pneumoniae and three salmonella enterica serovars, Typhimurium, Typhi and Paratyphi.
Article in Nucleic acids research, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
56 citing papers in PubMed, 122 citations in OpenAlex.
- Chronic granulomatous disease: Clinical, microbial, and genetic findings in 39 Colombian patients.Journal of human immunity · 2026Article
- Experimental promoter identification of a foodborne pathogenFrontiers in microbiology · 2023Article
- The Molecular Basis forViruses · 2021Article
- A method for achieving complete microbial genomes and improving bins from metagenomics data.PLoS computational biology · 2021Article
- Genetic Characterization of AmpC and Extended-Spectrum Beta-Lactamase Phenotypes inFrontiers in cellular and infection microbiology · 2021Article
- Deep phenotypic characterization of immunization-induced antibacterial IgG repertoires in mice using a single-antibody bioassay.Communications biology · 2020Article
- Combined Effect of Modified Atmosphere Packaging and UV-C Radiation on Pathogens Reduction, Biogenic Amines, and Shelf Life of Refrigerated Tilapia (Molecules (Basel, Switzerland) · 2020Article
- Limited Evolutionary Conservation of the Phenotypic Effects of Antibiotic Resistance Mutations.Molecular biology and evolution · 2019Article
- Identification of Genes Involved in Biogenesis of Outer Membrane Vesicles (OMVs) inFrontiers in microbiology · 2019Article
- Genetic Adaptation to Growth Under Laboratory Conditions inFrontiers in microbiology · 2018Article
- Interplay between tolerance mechanisms to copper and acid stress inProceedings of the National Academy of Sciences of the United States of America · 2017Article
- The Negative Effects of KPN00353 on Glycerol Kinase and Microaerobic 1,3-Propanediol Production inFrontiers in microbiology · 2017Article
- The Effectors and Sensory Sites of Formaldehyde-responsive Regulator FrmR and Metal-sensing Variant.The Journal of biological chemistry · 2016Article
- Loss of the lac operon contributes to Salmonella invasion of epithelial cells through derepression of flagellar synthesis.Current microbiology · 2015Article
- Genomic characterisation of invasive non-typhoidal Salmonella enterica Subspecies enterica Serovar Bovismorbificans isolates from Malawi.PLoS neglected tropical diseases · 2013Article
- Two rep genes in small cryptic plasmid pKST21 of Escherichia coli.Current microbiology · 2013Article
- Elucidating the regulon of multidrug resistance regulator RarA in Klebsiella pneumoniae.Antimicrobial agents and chemotherapy · 2013Article
- Translesion DNA Synthesis.EcoSal Plus · 2012Article
- Characterization of RarA, a novel AraC family multidrug resistance regulator in Klebsiella pneumoniae.Antimicrobial agents and chemotherapy · 2012Article
- Comparative analysis of regulatory elements between Escherichia coli and Klebsiella pneumoniae by genome-wide transcription start site profiling.PLoS genetics · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
The Escherichia coli K-12 genome (ECO) was compared with the sampled genomes of the sibling species Salmonella enterica serovars Typhimurium, Typhi and Paratyphi A (collectively referred to as SAL) and the genome of the close outgroup Klebsiella pneumoniae (KPN). There are at least 160 locations where sequences of >400 bp are absent from ECO but present in the genomes of all three SAL and 394 locations where sequences are present in ECO but close homologs are absent in all SAL genomes. The 394 sequences in ECO that do not occur in SAL contain 1350 (30.6%) of the 4405 ECO genes. Of these, 1165 are missing from both SAL and KPN. Most of the 1165 genes are concentrated within 28 regions of 10-40 kb, which consist almost exclusively of such genes. Among these regions were six that included previously identified cryptic phage. A hypothetical ancestral state of genomic regions that differ between ECO and SAL can be inferred in some cases by reference to the genome structure in KPN and the more distant relative Yersinia pestis. However, many changes between ECO and SAL are concentrated in regions where all four genera have a different structure. The rate of gene insertion and deletion is sufficiently high in these regions that the ancestral state of the ECO/SAL lineage cannot be inferred from the present data. The sequencing of other closely related genomes, such as S.bongori or Citrobacter, may help in this regard.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.