ArticleProceedings of the National Academy of Sciences of the United States of America2000
Developmentally dynamic histone acetylation pattern of a tissue-specific chromatin domain.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 107 papers.
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Who cites it
107 citing papers in PubMed, 226 citations in OpenAlex.
- Review
- Exploring epigenetic and microRNA approaches for γ-globin gene regulation.Experimental biology and medicine (Maywood, N.J.) · 2021Review
- Co-Regulated Genes and Gene Clusters.Genes · 2021Review
- Chromatin accessibility maps provide evidence of multilineage gene priming in hematopoietic stem cells.Epigenetics & chromatin · 2021Article
- Article
- NuRD and CAF-1-mediated silencing of the D4Z4 array is modulated by DUX4-induced MBD3L proteins.eLife · 2018Article
- Fetal haemoglobin induction in sickle cell disease.British journal of haematology · 2018Review
- 3D genomics imposes evolution of the domain model of eukaryotic genome organization.Chromosoma · 2017Review
- Enhancer Regulation of Transcriptional Bursting Parameters Revealed by Forced Chromatin Looping.Molecular cell · 2016Article
- The androgen receptor controls expression of the cancer-associated sTn antigen and cell adhesion through induction of ST6GalNAc1 in prostate cancer.Oncotarget · 2015Article
- Chromatin looping and eRNA transcription precede the transcriptional activation of gene in the β-globin locus.Bioscience reports · 2015Article
- Hematopoietic transcriptional mechanisms: from locus-specific to genome-wide vantage points.Experimental hematology · 2014Review
- Quantifying ChIP-seq data: a spiking method providing an internal reference for sample-to-sample normalization.Genome research · 2014Article
- Role of LDB1 in the transition from chromatin looping to transcription activation.Genes & development · 2014Article
- Fascin is regulated by slug, promotes progression of pancreatic cancer in mice, and is associated with patient outcomes.Gastroenterology · 2014Article
- Article
- Establishment of a cell-type-specific genetic network by the mediator complex component Med1.Molecular and cellular biology · 2013Article
- Article
- The histone methyltransferase KMT2B is required for RNA polymerase II association and protection from DNA methylation at the MagohB CpG island promoter.Molecular and cellular biology · 2013Article
- Review
47 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
We have defined the histone acetylation pattern of the endogenous murine beta-globin domain, which contains the erythroidspecific beta-globin genes. The beta-globin locus control region (LCR) and transcriptionally active promoters were enriched in acetylated histones in fetal liver relative to fetal brain, whereas the inactive promoters were hypoacetylated. In contrast, the LCR and both active and inactive promoters were hyperacetylated in yolk sac. Hypersensitive site two of the LCR was also hyperacetylated in murine embryonic stem cells, whereas beta-globin promoters were hypoacetylated. Thus, the acetylation pattern varied at different developmental stages. Histone deacetylase inhibition selectively increased acetylation at a hypoacetylated promoter in fetal liver, suggesting that active deacetylation contributes to silencing of promoters. We propose that dynamic histone acetylation and deacetylation play an important role in the developmental control of beta-globin gene expression.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.