ArticleProceedings of the National Academy of Sciences of the United States of America2000
Yin6, a fission yeast Int6 homolog, complexes with Moe1 and plays a role in chromosome segregation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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28 citing papers in PubMed, 49 citations in OpenAlex.
- Analysis of Confounding Factors in Reactive Cysteine Profiling Reveals Enhanced Chromatin-Protein Association via CDK7 Inhibition by THZ1.ACS chemical biology · 2026Article
- Domain architecture of plant eukaryotic translation initiation factor 3 subunit E governs interaction with translational cis-elements to regulatepollen tube growth.The Plant cell · 2026Article
- eIF3 mRNA selectivity profiling reveals eIF3k as a cancer-relevant regulator of ribosome content.The EMBO journal · 2023Article
- Cdc48 influence on separase levels is independent of mitosis and suggests translational sensitivity of separase.Cell reports · 2022Article
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- The Drosophila orthologue of the INT6 onco-protein regulates mitotic microtubule growth and kinetochore structure.PLoS genetics · 2017Article
- A Transcript-Specific eIF3 Complex Mediates Global Translational Control of Energy Metabolism.Cell reports · 2016Article
- The Rice Eukaryotic Translation Initiation Factor 3 Subunit e (OseIF3e) Influences Organ Size and Pollen Maturation.Frontiers in plant science · 2016Article
- Int6 reduction activates stromal fibroblasts to enhance transforming activity in breast epithelial cells.Cell & bioscience · 2015Article
- Translation initiation factor eIF3h targets specific transcripts to polysomes during embryogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- A forward genetic screen identifies eukaryotic translation initiation factor 3, subunit H (eIF3h), as an enhancer of variegation in the mouse.G3 (Bethesda, Md.) · 2012Article
- INT6 interacts with MIF4GD/SLIP1 and is necessary for efficient histone mRNA translation.RNA (New York, N.Y.) · 2012Article
- Article
- Proteasome nuclear import mediated by Arc3 can influence efficient DNA damage repair and mitosis in Schizosaccharomyces pombe.Molecular biology of the cell · 2010Article
- Non-core subunit eIF3h of translation initiation factor eIF3 regulates zebrafish embryonic development.Developmental dynamics : an official publication of the American Association of Anatomists · 2010Article
- Int6 and Moe1 interact with Cdc48 to regulate ERAD and proper chromosome segregation.Cell cycle (Georgetown, Tex.) · 2010Article
- The eIF3 interactome reveals the translasome, a supercomplex linking protein synthesis and degradation machineries.Molecular cell · 2009Article
- Arabidopsis eIF3e interacts with subunits of the ribosome, Cop9 signalosome and proteasome.Plant signaling & behavior · 2008Article
- Isolation of the Schizosaccharomyces pombe proteasome subunit Rpn7 and a structure-function study of the proteasome-COP9-initiation factor domain.The Journal of biological chemistry · 2007Article
- Human INT6 interacts with MCM7 and regulates its stability during S phase of the cell cycle.Oncogene · 2007Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The INT6 gene has been implicated in human breast cancer formation, but its function is unknown. We isolated an Int6 homolog from fission yeast, Yin6, by its binding to a conserved protein in the Ras pathway, Moe1. Yin6 and Moe1 converge on the same protein complex to promote microtubule instability/disassembly. Yin6 and Moe1 interact cooperatively: when either protein is absent, the other becomes mislocalized with decreased protein levels. Furthermore, whereas full-length human Int6 rescues the phenotypes of the yin6-null (yin6Delta) mutant cells and binds human Moe1, truncated Int6 proteins found in tumors do not. Importantly, yin6Delta alone impairs chromosome segregation weakly, but yin6Delta together with ras1Delta causes severe chromosome missegregation. These data support a model in which INT6 mutations in humans either alone or together with additional mutations, such as a RAS mutation, may contribute to tumorigenesis by altering genome stability.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.