ArticleAntimicrobial agents and chemotherapy2001
In vitro susceptibility testing methods for caspofungin against Aspergillus and Fusarium isolates.
Article in Antimicrobial agents and chemotherapy, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00388167 (PROCAS), which is not on this map. Cited by 72 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
PROCAS: Study Observational Prospective and Multicenter to Determine the Clinic Effectiveness and the Safety of Caspofungin Acetate (CANCIDAS®) in the Treatment of Invader Fungal Infection
Who cites it
72 citing papers in PubMed.
- Article
- Fusariosis in cancer patients: 13 case series report and literature reviewBiomedica : revista del Instituto Nacional de Salud · 2023Review
- Pharmacodynamics, Mechanisms of Action and Resistance, and Spectrum of Activity of New Antifungal Agents.Journal of fungi (Basel, Switzerland) · 2022Review
- Antifungal Susceptibility Testing: A Primer for Clinicians.Open forum infectious diseases · 2021Review
- The Antifungal Pipeline: Fosmanogepix, Ibrexafungerp, Olorofim, Opelconazole, and Rezafungin.Drugs · 2021Review
- Manogepix, the Active Moiety of the Investigational Agent Fosmanogepix, DemonstratesAntimicrobial agents and chemotherapy · 2021Article
- Antifungal susceptibility profiles of otomycosis etiological agents in Ahvaz, Iran.Current medical mycology · 2020Article
- APX001 and Other Gwt1 Inhibitor Prodrugs Are Effective in ExperimentalAntimicrobial agents and chemotherapy · 2019Article
- Induction of Mitochondrial Reactive Oxygen Species Production by Itraconazole, Terbinafine, and Amphotericin B as a Mode of Action against Aspergillus fumigatus.Antimicrobial agents and chemotherapy · 2017Article
- Fusarium Keratitis in Germany.Journal of clinical microbiology · 2017Article
- Review
- Engineering of New Pneumocandin Side-Chain Analogues from Glarea lozoyensis by Mutasynthesis and Evaluation of Their Antifungal Activity.ACS chemical biology · 2016Article
- Fusariosis in a Patient with Acute Myeloid Leukemia: A Case Report and Review of the Literature.Mycopathologia · 2016Review
- Multilaboratory Evaluation of In Vitro Antifungal Susceptibility Testing of Dermatophytes for ME1111.Journal of clinical microbiology · 2016Article
- Albumin Enhances Caspofungin Activity against Aspergillus Species by Facilitating Drug Delivery to Germinating Hyphae.Antimicrobial agents and chemotherapy · 2015Article
- Caspofungin Treatment of Aspergillus fumigatus Results in ChsG-Dependent Upregulation of Chitin Synthesis and the Formation of Chitin-Rich Microcolonies.Antimicrobial agents and chemotherapy · 2015Article
- In vitro activity of calcineurin and heat shock protein 90 Inhibitors against Aspergillus fumigatus azole- and echinocandin-resistant strains.Antimicrobial agents and chemotherapy · 2013Article
- Combination of voriconazole and anidulafungin for treatment of triazole-resistant aspergillus fumigatus in an in vitro model of invasive pulmonary aspergillosis.Antimicrobial agents and chemotherapy · 2012Article
- In vitro combination of anidulafungin and voriconazole against intrinsically azole-susceptible and -resistant Aspergillus spp.Antimicrobial agents and chemotherapy · 2012Article
- The composition of the culture medium influences the β-1,3-glucan metabolism of Aspergillus fumigatus and the antifungal activity of inhibitors of β-1,3-glucan synthesis.Antimicrobial agents and chemotherapy · 2012Article
12 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated the relevance of prominent reduction in turbidity macroscopically (MIC) and formation of aberrant hyphal tips microscopically (minimum effective concentration; MEC) in measuring the in vitro activity of caspofungin against Aspergillus and Fusarium. Caspofungin generated low MICs and MECs against Aspergillus, but not for Fusarium. While MICs increased inconsistently when the incubation time was prolonged, MEC appeared as a stable and potentially relevant endpoint in testing in vitro caspofungin activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.