ArticleThe Journal of experimental medicine2000
Virus-induced maturation and activation of autoreactive memory B cells.
Article in The Journal of experimental medicine, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 26 citations in OpenAlex.
- B-lymphocyte homeostasis and BLyS-directed immunotherapy in transplantation.Transplantation reviews (Orlando, Fla.) · 2010Review
- Deletion of IgG-switched autoreactive B cells and defects in Fas(lpr) lupus mice.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- ICOS expression by effector T cells influences the ability of regulatory T cells to inhibit anti-chromatin B cell responses in recipient mice.Journal of autoimmunity · 2010Article
- Efficient help for autoreactive B-cell activation requires CD4+ T-cell recognition of an agonist peptide at the effector stage.European journal of immunology · 2009Article
- Influenza virus-induced type I interferon leads to polyclonal B-cell activation but does not break down B-cell tolerance.Journal of virology · 2007Article
- Autoantigen, innate immunity, and T cells cooperate to break B cell tolerance during bacterial infection.The Journal of clinical investigation · 2005Article
- A fail-safe mechanism for negative selection of isotype-switched B cell precursors is regulated by the Fas/FasL pathway.The Journal of experimental medicine · 2003Article
- Therapeutic CD154 antibody for lupus: promise for the future?The Journal of clinical investigation · 2003Article
- Mechanisms, manifestations, and failures of self-tolerance.Immunologic research · 2003Review
- Naive and memory B cells in T-cell-dependent and T-independent responses.Springer seminars in immunopathology · 2001Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
We have examined B cell populations that participate in distinct phases of the immune response to the influenza virus A/PR/8/34 hemagglutinin (HA) for their susceptibility to negative selection in mice that express the HA as a neo-self-antigen (HA104 mice). We demonstrated previously that specificity for the neo-self-HA causes a population of immunoglobulin G antibody-secreting cells, which dominate the primary response to virus immunization in BALB/c mice, to be negatively selected in HA104 mice. We find here that in contrast to these primary response B cells, HA-specific memory response B cells developed equivalently in HA104 and nontransgenic (BALB/c) mice. Indeed, there was no indication that HA-specific B cells were negatively selected during memory formation in influenza virus-immunized HA104 mice, even though the neo-self-HA can be recognized by memory B cells. Furthermore, HA-specific autoantibodies were induced in the absence of virus immunization by mating HA104 mice with mice transgenic for a CD4(+) HA-specific T cell receptor. These findings indicate that specificity for a self-antigen does not prevent the maturation of autoreactive B cells in the germinal center pathway. Rather, the availability of CD4(+) T cell help may play a crucial role in regulating autoantibody responses to the HA in HA104 mice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.