ArticleJournal of virology2001
The ability of integrin alpha(v)beta(3) To function as a receptor for foot-and-mouth disease virus is not dependent on the presence of complete subunit cytoplasmic domains.
Article in Journal of virology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 32 citations in OpenAlex.
- How foot-and-mouth disease virus receptor mediates foot-and-mouth disease virus infection.Virology journal · 2015Review
- Establishment and evaluation of a murine ανβ3-integrin-expressing cell line with increased susceptibility to Foot-and-mouth disease virus.Journal of veterinary science · 2015Article
- Integrin β3 is required in infection and proliferation of classical swine fever virus.PloS one · 2014Article
- Mechanisms of foot-and-mouth disease virus tropism inferred from differential tissue gene expression.PloS one · 2013Article
- Analysis of foot-and-mouth disease virus internalization events in cultured cells.Journal of virology · 2005Article
- Use of confocal immunofluorescence microscopy to localize viral nonstructural proteins and potential sites of replication in pigs experimentally infected with foot-and-mouth disease virus.Journal of virology · 2005Article
- Interactions of foot-and-mouth disease virus with soluble bovine alphaVbeta3 and alphaVbeta6 integrins.Journal of virology · 2004Article
- Integrin alphavbeta8 functions as a receptor for foot-and-mouth disease virus: role of the beta-chain cytodomain in integrin-mediated infection.Journal of virology · 2004Article
- Foot-and-mouth disease.Clinical microbiology reviews · 2004Review
- Foot-and-mouth disease virus receptors: comparison of bovine alpha(V) integrin utilization by type A and O viruses.Journal of virology · 2003Article
- Selection of peptide entry motifs by bacterial surface display.The Biochemical journal · 2002Article
- Macrophage phagocytosis of foot-and-mouth disease virus may create infectious carriers.Immunology · 2002Article
- Role of the cytoplasmic domain of the beta-subunit of integrin alpha(v)beta6 in infection by foot-and-mouth disease virus.Journal of virology · 2001Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The integrin alpha(v)beta(3) has been shown to function as one of the integrin receptors on cultured cells for foot-and-mouth disease virus (FMDV), and high-efficiency utilization of the bovine homolog of this integrin is dependent on the cysteine-rich repeat region of the bovine beta(3) subunit. In this study we have examined the role of the cytoplasmic domains of the alpha(v) and beta(3) subunits in FMDV infection. We have found that truncations or extensions of these domains of either subunit, including deletions removing almost all of the cytoplasmic domains, had little or no effect on the ability of the integrin to function as a receptor for FMDV. The lysosomotropic agent monensin inhibited viral replication in cells transfected with either intact or cytoplasmic domain-truncated alpha(v)beta(3). In addition, viral replication in transfected cells was inhibited by an alpha(v)beta(3) function-blocking antibody but not by function-blocking antibodies to three other RGD-directed integrins, suggesting that these integrins are not involved in the infectious process. These results indicate that alterations to the cytoplasmic domains of either subunit, which lead to the inability of the integrin receptor to function normally, do not abolish the ability of the integrin to bind and internalize this viral ligand.
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