ArticleJournal of virology2001
Duck hepatitis B virus expresses a regulatory HBx-like protein from a hidden open reading frame.
Article in Journal of virology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 54 citations in OpenAlex.
- Review
- New Avian Hepadnavirus in Palaeognathous Bird, Germany.Emerging infectious diseases · 2017Article
- Hepatitis B virus X protein crosses out Smc5/6 complex to maintain covalently closed circular DNA transcription.Hepatology (Baltimore, Md.) · 2016Article
- Early mesozoic coexistence of amniotes and hepadnaviridae.PLoS genetics · 2014Article
- Hepatitis B virus lineages in mammalian hosts: potential for bidirectional cross-species transmission.World journal of gastroenterology · 2014Review
- The C-terminal region of the hepatitis B virus X protein is essential for its stability and function.Virus research · 2011Article
- Pre-P is a secreted glycoprotein encoded as an N-terminal extension of the duck hepatitis B virus polymerase gene.Journal of virology · 2009Article
- Hepatitis B virus HBx protein localizes to mitochondria in primary rat hepatocytes and modulates mitochondrial membrane potential.Journal of virology · 2008Article
- Avian hepatitis B viruses: molecular and cellular biology, phylogenesis, and host tropism.World journal of gastroenterology · 2007Review
- Hepatitis B virus-induced oncogenesis.World journal of gastroenterology · 2007Review
- Differential effects on apoptosis induction in hepatocyte lines by stable expression of hepatitis B virus X protein.World journal of gastroenterology · 2006Article
- Activation of focal adhesion kinase by hepatitis B virus HBx protein: multiple functions in viral replication.Journal of virology · 2006Article
- Identification and characterization of avihepadnaviruses isolated from exotic anseriformes maintained in captivity.Journal of virology · 2005Article
- The enigmatic X gene of hepatitis B virus.Journal of virology · 2004Review
- Establishment of mice model with human viral hepatitis B.World journal of gastroenterology · 2004Article
- Molecular characterization of duck hepatitis B virus isolates from South African ducks.Virus genes · 2004Article
- New hepatitis B virus of cranes that has an unexpected broad host range.Journal of virology · 2003Article
- Conserved transactivating and pro-apoptotic functions of hepadnaviral X protein in ortho- and avihepadnaviruses.Oncogene · 2002Article
- X-deficient woodchuck hepatitis virus mutants behave like attenuated viruses and induce protective immunity in vivo.The Journal of clinical investigation · 2001Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Duck hepatitis B viruses (DHBV), unlike mammalian hepadnaviruses, are thought to lack X genes, which encode transcription-regulatory proteins believed to contribute to the development of hepatocellular carcinoma. A lack of association of chronic DHBV infection with hepatocellular carcinoma development supports this belief. Here, we demonstrate that DHBV genomes have a hidden open reading frame from which a transcription-regulatory protein, designated DHBx, is expressed both in vitro and in vivo. We show that DHBx enhances neither viral protein expression, intracellular DNA synthesis, nor virion production when assayed in the full-length genome context in LMH cells. However, similar to mammalian hepadnavirus X proteins, DHBx activates cellular and viral promoters via the Raf-mitogen-activated protein kinase signaling pathway and localizes primarily in the cytoplasm. The functional similarities as well as the weak sequence homologies of DHBx and the X proteins of mammalian hepadnaviruses strongly suggest a common ancestry of ortho- and avihepadnavirus X genes. In addition, our data disclose similar intracellular localization and transcription regulatory functions of the corresponding proteins, raise new questions as to their presumed role in hepatocarcinogenesis, and imply unique opportunities for deciphering of their still-enigmatic in vivo functions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.