ArticleJournal of virology2001
Gps2, a protein partner for human papillomavirus E6 proteins.
Article in Journal of virology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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Who cites it
25 citing papers in PubMed.
- Interaction of NEP with G Protein Pathway Suppressor 2 Facilitates Influenza A Virus Replication by Weakening the Inhibition of GPS2 to RNA Synthesis and Ribonucleoprotein Assembly.Journal of virology · 2021Article
- The human papillomavirus oncoproteins: a review of the host pathways targeted on the road to transformation.The Journal of general virology · 2021Review
- Sterile α Motif Domain Containing 9 Is a Novel Cellular Interacting Partner to Low-Risk Type Human Papillomavirus E6 Proteins.PloS one · 2016Article
- Papillomavirus E6 oncoproteins.Virology · 2013Review
- Activation of cap-dependent translation by mucosal human papillomavirus E6 proteins is dependent on the integrity of the LXXLL binding motif.Journal of virology · 2012Article
- Structural basis for the assembly of the SMRT/NCoR core transcriptional repression machinery.Nature structural & molecular biology · 2011Article
- Papillomavirus E6 proteins.Virology · 2009Review
- Human papilloma virus (HPV) and host cellular interactions.Pathology oncology research : POR · 2008Review
- G-protein pathway suppressor 2 (GPS2) interacts with the regulatory factor X4 variant 3 (RFX4_v3) and functions as a transcriptional co-activator.The Journal of biological chemistry · 2008Article
- Cellular binding partners of the human papillomavirus E6 protein.Archives of virology · 2008Review
- PATJ, a tight junction-associated PDZ protein, is a novel degradation target of high-risk human papillomavirus E6 and the alternatively spliced isoform 18 E6.Journal of virology · 2007Article
- Structures of a human papillomavirus (HPV) E6 polypeptide bound to MAGUK proteins: mechanisms of targeting tumor suppressors by a high-risk HPV oncoprotein.Journal of virology · 2007Article
- Biomarkers in cervical cancer.Biomarker insights · 2007Article
- Modulation of apoptosis by human papillomavirus (HPV) oncoproteins.Archives of virology · 2006Review
- The E6 protein of the cutaneous human papillomavirus type 8 can stimulate the viral early and late promoters by distinct mechanisms.Journal of virology · 2006Article
- Presence of papillomavirus sequences in condylomatous lesions of the mamillae and in invasive carcinoma of the breast.Breast cancer research : BCR · 2005Article
- Role of the PDZ domain-binding motif of the oncoprotein E6 in the pathogenesis of human papillomavirus type 31.Journal of virology · 2004Article
- Pathogenesis of human papillomaviruses in differentiating epithelia.Microbiology and molecular biology reviews : MMBR · 2004Review
- Roles of the E6 and E7 proteins in the life cycle of low-risk human papillomavirus type 11.Journal of virology · 2004Article
- A mutant of human papillomavirus type 16 E6 deficient in binding alpha-helix partners displays reduced oncogenic potential in vivo.Journal of virology · 2002Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have used the yeast two-hybrid system to screen a cDNA library prepared from normal human epidermal keratinocytes and identified protein partners for human papilloma virus (HPV) E6 proteins. A clone that encoded Gps2 interacted with E6 proteins from HPVs of high and low oncogenic risk. The specificity of these reactions was verified and the regions of E6 that were required for interaction were mapped. Steady-state and pulse-chase analyses of cells cotransfected with DNAs expressing E6 from either HPV6 or HPV18 and Gps2 demonstrated that the E6 proteins induced the degradation of Gps2 in vivo but not in vitro. Gps2 exhibited transcriptional activation activity, and high-risk E6 suppressed this activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.