ArticleJournal of virology2001
Interaction between the open reading frame III product and the coat protein is required for transmission of cauliflower mosaic virus by aphids.
Article in Journal of virology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- The cauliflower mosaic virus transmission helper protein P2 modifies directly the probing behavior of the aphid vector Myzus persicae to facilitate transmission.PLoS pathogens · 2023Article
- Cauliflower mosaic virus Transcriptome Reveals a Complex Alternative Splicing Pattern.PloS one · 2015Article
- Cauliflower mosaic virus major inclusion body protein interacts with the aphid transmission factor, the virion-associated protein, and gene VII product.Virus research · 2012Article
- Intracellular transport of plant viruses: finding the door out of the cell.Molecular plant · 2011Review
- Structural insights into viral determinants of nematode mediated Grapevine fanleaf virus transmission.PLoS pathogens · 2011Article
- Structural insights into the molecular mechanisms of cauliflower mosaic virus transmission by its insect vector.Journal of virology · 2010Article
- A single amino acid position in the helper component of cauliflower mosaic virus can change the spectrum of transmitting vector species.Journal of virology · 2005Article
- A coiled-coil interaction mediates cauliflower mosaic virus cell-to-cell movement.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- A conserved capsid protein surface domain of Cucumber mosaic virus is essential for efficient aphid vector transmission.Journal of virology · 2002Article
- The cauliflower mosaic virus virion-associated protein is dispensable for viral replication in single cells.Journal of virology · 2002Article
- Intracellular distribution of viral gene products regulates a complex mechanism of cauliflower mosaic virus acquisition by its aphid vector.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Biochemical characterization of the helper component of Cauliflower mosaic virus.Journal of virology · 2001Article
- Tetramerization is a conserved feature of the virion-associated protein in plant pararetroviruses.Journal of virology · 2001Article
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Authors and funding
7 authors.
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Abstract
Transmission of cauliflower mosaic virus (CaMV) by aphids requires two viral nonstructural proteins, the open reading frame (ORF) II and ORF III products (P2 and P3). An interaction between a C-terminal domain of P2 and an N-terminal domain of P3 is essential for transmission. Purified particles of CaMV are efficiently transmitted only if aphids, previously fed a P2-containing solution, are allowed to acquire a preincubated mixture of P3 and virions in a second feed, thus suggesting a direct interaction between P3 and coat protein. Herein we demonstrate that P3 directly interacts with purified viral particles and unassembled coat protein without the need for any other factor and that P3 mediates the association of P2 with purified virus particles. The interaction domain of P3 is located in its C-terminal half, downstream of the P3-P2 interaction domain but overlapping a region which binds nucleic acids. Mutagenesis of P3 which interferes with the interaction between P3 and virions is correlated with the loss of transmission by aphids. Taken together, our results demonstrate that P3 plays a crucial role in the formation of the CaMV transmissible complex by serving as a bridge between P2 and virus particles.
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