ArticleJournal of virology2001
CD4(+) T cells and gamma interferon in the long-term control of persistent friend retrovirus infection.
Article in Journal of virology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 54 citations in OpenAlex.
- A single dominant locus restricts retrovirus replication in YBR/Ei mice.Journal of virology · 2023Article
- Cytotoxic CD4Frontiers in immunology · 2023Review
- HIV-Resistant and HIV-Specific CAR-Modified CD4Molecular therapy : the journal of the American Society of Gene Therapy · 2020Article
- Friend retrovirus studies reveal complex interactions between intrinsic, innate and adaptive immunity.FEMS microbiology reviews · 2019Review
- Fas Ligand-mediated cytotoxicity of CD4+ T cells during chronic retrovirus infection.Scientific reports · 2017Article
- CD69 Deficiency Enhances the Host Response to Vaccinia Virus Infection through Altered NK Cell Homeostasis.Journal of virology · 2016Article
- Combination of nanoparticle-based therapeutic vaccination and transient ablation of regulatory T cells enhances anti-viral immunity during chronic retroviral infection.Retrovirology · 2016Review
- Role of regulatory T cells during virus infection.Immunological reviews · 2013Review
- CD4+ T cells develop antiretroviral cytotoxic activity in the absence of regulatory T cells and CD8+ T cells.Journal of virology · 2013Article
- CD4 T cell responses in latent and chronic viral infections.Frontiers in immunology · 2013Article
- Expanding roles for CD4⁺ T cells in immunity to viruses.Nature reviews. Immunology · 2012Review
- Immunotherapy of human papilloma virus induced disease.The open virology journal · 2012Article
- Distinct roles of CD4+ T cell subpopulations in retroviral immunity: lessons from the Friend virus mouse model.Retrovirology · 2011Review
- Improved vaccine protection against retrovirus infection after co-administration of adenoviral vectors encoding viral antigens and type I interferon subtypes.Retrovirology · 2011Article
- Effects of acute and chronic murine norovirus infections on immune responses and recovery from Friend retrovirus infection.Journal of virology · 2009Article
- Race between retroviral spread and CD4+ T-cell response determines the outcome of acute Friend virus infection.Journal of virology · 2009Article
- Tissue-specific abundance of regulatory T cells correlates with CD8+ T cell dysfunction and chronic retrovirus loads.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- Article
- CD137 costimulation of CD8+ T cells confers resistance to suppression by virus-induced regulatory T cells.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Natural regulatory T cells and persistent viral infection.Journal of virology · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
We have used the Friend virus model to determine the basic mechanisms by which the immune system can control persistent retroviral infections. Previously we showed that CD4(+) T cells play an essential role in keeping persistent retrovirus in check. The present in vitro experiments with a Friend virus-specific CD4(+) T-cell clone revealed that these cells produce gamma interferon (IFN-gamma), which acts with two distinct mechanisms of antiviral activity. First, IFN-gamma had a direct inhibitory effect on virus production. This inhibitory effect was noncytolytic and, interestingly, was not associated with decreased cell surface expression of viral antigens. The second mechanism of IFN-gamma-mediated antiviral activity was an enhancement of CD4(+) T-cell-mediated cytolytic activity. We also found an in vivo role for IFN-gamma in the control of persistent Friend virus infections. Neutralization of IFN-gamma in persistently infected mice resulted in significantly increased levels of virus in the spleen, and a significant percentage of IFN-gamma-deficient mice were unable to maintain long-term control over Friend virus infections.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.