ArticleInfection and immunity2001
Legionella pneumophila entry gene rtxA is involved in virulence.
Article in Infection and immunity, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
64 citing papers in PubMed, 112 citations in OpenAlex.
- The hidden dancers in water: the symbiotic mystery ofFrontiers in microbiology · 2025Review
- Legionella pneumophila cell surface RtxA release by LapD/LapG and its role in virulence.BMC microbiology · 2024Article
- The Legionella collagen-like protein employs a distinct binding mechanism for the recognition of host glycosaminoglycans.Nature communications · 2024Article
- Virulence Genes and Biofilm Formation Among Legionella pneumophila Isolates Collected from Hospital Water Sources.Current microbiology · 2024Article
- A rapid and reliable method for earlyFrontiers in microbiology · 2024Article
- Evaluation of Genetic Diversity and Virulence Potential ofPathogens (Basel, Switzerland) · 2023Article
- Comparative Genomics ofMicroorganisms · 2023Article
- Whole-genome sequencing of the clinical isolate ofEuropean clinical respiratory journal · 2023Article
- Concept about the Virulence Factor ofMicroorganisms · 2022Review
- TheMicrobiology spectrum · 2022Article
- Migration of Acanthamoeba through Legionella biofilms is regulated by the bacterial Lqs-LvbR network, effector proteins and the flagellum.Environmental microbiology · 2022Article
- Legionella pneumophila Risk from Cooling Tower Systems in China.Applied and environmental microbiology · 2022Article
- Growth by Insertion: The Family of Bacterial DDxP Proteins.International journal of molecular sciences · 2020Article
- Essential role of calcium in extending RTX adhesins to their target.Journal of structural biology: X · 2020Article
- Article
- Legionnaires' Disease Mortality in Guinea Pigs Involves the p45 Mobile Genomic Element.The Journal of infectious diseases · 2019Article
- The Role ofFrontiers in microbiology · 2019Article
- Legionella pneumophila p45 element influences host cell entry and sensitivity to sodium.PloS one · 2019Article
- Type 1 Does the Two-Step: Type 1 Secretion Substrates with a Functional Periplasmic Intermediate.Journal of bacteriology · 2018Review
- An N-Terminal Retention Module Anchors the Giant Adhesin LapA of Pseudomonas fluorescens at the Cell Surface: a Novel Subfamily of Type I Secretion Systems.Journal of bacteriology · 2018Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Successful parasitism of host cells by intracellular pathogens involves adherence, entry, survival, intracellular replication, and cell-to-cell spread. Our laboratory has been examining the role of early events, adherence and entry, in the pathogenesis of the facultative intracellular pathogen Legionella pneumophila. Currently, the mechanisms used by L. pneumophila to gain access to the intracellular environment are not well understood. We have recently isolated three loci, designated enh1, enh2, and enh3, that are involved in the ability of L. pneumophila to enter host cells. One of the genes present in the enh1 locus, rtxA, is homologous to repeats in structural toxin genes (RTX) found in many bacterial pathogens. RTX proteins from other bacterial species are commonly cytotoxic, and some of them have been shown to bind to beta(2) integrin receptors. In the current study, we demonstrate that the L. pneumophila rtxA gene is involved in adherence, cytotoxicity, and pore formation in addition to its role in entry. Furthermore, an rtxA mutant does not replicate as well as wild-type L. pneumophila in monocytes and is less virulent in mice. Thus, we conclude that the entry gene rtxA is an important virulence determinant in L. pneumophila and is likely to be critical for the production of Legionnaires' disease in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.