ArticleInfection and immunity2001
Biochemical and biological properties of Staphylococcal enterotoxin K.
Article in Infection and immunity, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 52 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed, 212 citations in OpenAlex.
- Genomic characterization of healthcare-associated ST5 MRSA causing severe pseudomembranous enteritis in intensive care unit.BMC infectious diseases · 2025Article
- Superantigens, a Paradox of the Immune Response.Toxins · 2022Review
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- Enterotoxigenic Potential of Coagulase-Negative Staphylococci from Ready-to-Eat Food.Pathogens (Basel, Switzerland) · 2020Article
- Modeling of Effective Antimicrobials to ReduceToxins · 2020Article
- The T cell activating properties and antitumour activity of Staphylococcal Enterotoxin-like Q.Medical microbiology and immunology · 2019Article
- Transcriptomic Adjustments ofFrontiers in microbiology · 2019Article
- Article
- Basis of Virulence in Enterotoxin-Mediated Staphylococcal Food Poisoning.Frontiers in microbiology · 2018Review
- Antimicrobial resistance and prevalence of CvfB, SEK and SEQ genes amongExperimental and therapeutic medicine · 2017Article
- Monoclonal antibodies protect from Staphylococcal Enterotoxin K (SEK) induced toxic shock and sepsis by USA300 Staphylococcus aureus.Virulence · 2017Article
- A comparison of virulence patterns and in vivo fitness between hospital- and community-acquired methicillin-resistant Staphylococcus aureus related to the USA400 clone.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2015Article
- CD4+ T cells promote the pathogenesis of Staphylococcus aureus pneumonia.The Journal of infectious diseases · 2015Article
- Prevalence of enterotoxigenic Staphylococcus aureus in organic milk and cheese in Tabriz, Iran.Iranian journal of microbiology · 2014Article
- Detection and measurement of staphylococcal enterotoxin-like K (SEl-K) secretion by Staphylococcus aureus clinical isolates.Journal of clinical microbiology · 2014Article
- Staphylococcal enterotoxins in the etiopathogenesis of mucosal autoimmunity within the gastrointestinal tract.Toxins · 2014Review
- Enterotoxin gene profiles among Staphylococcus aureus isolated from raw milk.Iranian journal of veterinary research · 2014Article
- Emetic potentials of newly identified staphylococcal enterotoxin-like toxins.Infection and immunity · 2013Article
- Staphylococcal and streptococcal superantigen exotoxins.Clinical microbiology reviews · 2013Review
- Detection of the enterotoxigenic genes (Comparative clinical pathology · 2013Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Staphylococcus aureus is an important human pathogen which is implicated in a wide variety of diseases. Major determinants of the virulence of this organism include extracellular virulence factors. Staphylococcal enterotoxins (SEs) are important causative agents in staphylococcal toxic shock syndrome and food poisoning. Our study identified a novel enterotoxin, SEK, and examined its biochemical and biological properties. SEK had a molecular weight of 26,000 and an experimentally determined pI of between 7.0 and 7.5. SEK was secreted by clinical isolates of S. aureus. We demonstrated that SEK had many of the biological activities associated with the SEs, including superantigenicity, pyrogenicity, the ability to enhance the lethal effect of endotoxin, and lethality in a rabbit model when administered by subcutaneous miniosmotic pump. Recombinant SEK was shown to stimulate human CD4(+) and CD8(+) T cells in a Vbeta-specific manner; T-cells bearing Vbeta 5.1, 5.2, and 6.7 were significantly stimulated to proliferate.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.