ArticleInfection and immunity2001
Inactivation of the srtA gene in Streptococcus gordonii inhibits cell wall anchoring of surface proteins and decreases in vitro and in vivo adhesion.
Article in Infection and immunity, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
45 citing papers in PubMed, 106 citations in OpenAlex.
- Molecular basis and therapeutic potential of sortase A inhibitors as new antibiotics against MDR pathogens.Open biology · 2026Review
- Advances in Kaempferol: Extraction, Biosynthesis, and Application with Antibacterial Agents.Antibiotics (Basel, Switzerland) · 2025Review
- Covalent sortase A inhibitor ML346 preventsRSC medicinal chemistry · 2022Article
- Article
- State-of-the-Art Vaccine Research for Aquaculture Use: The Case of Three Economically Relevant Fish Species.Vaccines · 2021Review
- Uncovering Roles of Streptococcus gordonii SrtA-Processed Proteins in the Biofilm Lifestyle.Journal of bacteriology · 2020Article
- Astilbin Inhibits the Activity of Sortase A fromMolecules (Basel, Switzerland) · 2019Article
- Role of Neuraminidase-Producing Bacteria in Exposing Cryptic Carbohydrate Receptors for Streptococcus gordonii Adherence.Infection and immunity · 2018Article
- Ca2+ binding induced sequential allosteric activation of sortase A: An example for ion-triggered conformational selection.PloS one · 2018Article
- Epigallocatechin gallate inhibits Streptococcus pneumoniae virulence by simultaneously targeting pneumolysin and sortase A.Journal of cellular and molecular medicine · 2017Article
- Article
- Equilibrium of sortase A dimerization on Staphylococcus aureus cell surface mediates its cell wall sorting activity.Experimental biology and medicine (Maywood, N.J.) · 2016Article
- Streptococcus pyogenes Sortase Mutants Are Highly Susceptible to Killing by Host Factors Due to Aberrant Envelope Physiology.PloS one · 2015Article
- Lethality of sortase depletion in Actinomyces oris caused by excessive membrane accumulation of a surface glycoprotein.Molecular microbiology · 2014Article
- Clostridium difficile has a single sortase, SrtB, that can be inhibited by small-molecule inhibitors.BMC microbiology · 2014Article
- Impact of Lactobacillus plantarum sortase on target protein sorting, gastrointestinal persistence, and host immune response modulation.Journal of bacteriology · 2013Article
- Synthesis and structure activity relationship studies of novel Staphylococcus aureus Sortase A inhibitors.European journal of medicinal chemistry · 2010Article
- Discovery and structure-activity relationship analysis of Staphylococcus aureus sortase A inhibitors.Bioorganic & medicinal chemistry · 2009Article
- Sortase A confers protection against Streptococcus pneumoniae in mice.Infection and immunity · 2009Article
- Identification of novel LPXTG-linked surface proteins from Streptococcus gordonii.Microbiology (Reading, England) · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The srtA gene product, SrtA, has been shown to be required for cell wall anchoring of protein A as well as virulence in the pathogenic bacterium Staphylococcus aureus. There are five major mechanisms for displaying proteins at the surface of gram-positive bacteria (P. Cossart and R. Jonquieres, Proc. Natl. Acad. Sci. USA 97:5013-5015, 2000). However, since many of the known surface proteins of gram-positive bacteria are believed to be exported and anchored via the sortase pathway, it was of interest to determine if srtA plays a similar role in other gram-positive bacteria. To that end, the srtA gene in the human oral commensal organism Streptococcus gordonii was insertionally inactivated. The srtA mutant S. gordonii exhibited a marked reduction in quantity of a specific anchored surface protein. Furthermore, the srtA mutant had reduced binding to immobilized human fibronectin and had a decreased ability to colonize the oral mucosa of mice. Taken together, these results suggest that the activity of SrtA plays an important role in the biology of nonpathogenic as well as pathogenic gram-positive cocci.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.