ArticleInfection and immunity2001
Role of flm locus in mesophilic Aeromonas species adherence.
Article in Infection and immunity, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 54 citations in OpenAlex.
- Characterization of the role of putativeJournal of bacteriology · 2026Article
- Heterogeneous glycosylation and methylation of the Aeromonas caviae flagellin.MicrobiologyOpen · 2022Article
- The Animal Model Determines the Results ofFrontiers in microbiology · 2016Article
- Cross-Talk between the Aeromonas hydrophila Type III Secretion System and Lateral Flagella System.Frontiers in microbiology · 2016Article
- The Aeromonas caviae AHA0618 gene modulates cell length and influences swimming and swarming motility.MicrobiologyOpen · 2015Article
- Maf-dependent bacterial flagellin glycosylation occurs before chaperone binding and flagellar T3SS export.Molecular microbiology · 2014Article
- Characterization of protein glycosylation in Francisella tularensis subsp. holarctica: identification of a novel glycosylated lipoprotein required for virulence.Molecular & cellular proteomics : MCP · 2012Article
- Identification of a putative glycosyltransferase responsible for the transfer of pseudaminic acid onto the polar flagellin of Aeromonas caviae Sch3N.MicrobiologyOpen · 2012Article
- Bundle-forming pilus locus of Aeromonas veronii bv. Sobria.Infection and immunity · 2012Article
- The main Aeromonas pathogenic factors.ISRN microbiology · 2012Article
- A UDP-HexNAc:polyprenol-P GalNAc-1-P transferase (WecP) representing a new subgroup of the enzyme family.Journal of bacteriology · 2011Article
- The structural diversity of carbohydrate antigens of selected gram-negative marine bacteria.Marine drugs · 2011Review
- Structural and functional analysis of Campylobacter jejuni PseG: a udp-sugar hydrolase from the pseudaminic acid biosynthetic pathway.The Journal of biological chemistry · 2009Article
- An Aeromonas caviae genomic island is required for both O-antigen lipopolysaccharide biosynthesis and flagellin glycosylation.Journal of bacteriology · 2009Article
- Large-scale transposon mutagenesis of Photobacterium profundum SS9 reveals new genetic loci important for growth at low temperature and high pressure.Journal of bacteriology · 2008Article
- Genome sequence of Aeromonas hydrophila ATCC 7966T: jack of all trades.Journal of bacteriology · 2006Article
- Polar flagellum biogenesis in Aeromonas hydrophila.Journal of bacteriology · 2006Article
- The ability of Proteus mirabilis to sense surfaces and regulate virulence gene expression involves FliL, a flagellar basal body protein.Journal of bacteriology · 2005Article
- Laterally transferred elements and high pressure adaptation in Photobacterium profundum strains.BMC genomics · 2005Article
- Flagellin from Listeria monocytogenes is glycosylated with beta-O-linked N-acetylglucosamine.Journal of bacteriology · 2004Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The adherence mechanism of Aeromonas caviae Sch3N to HEp-2 cells was initially investigated through four mini-Tn5 mutants that showed a 10-fold decrease in adherence. These mutants lost motility, flagella, and their lipopolysaccharide (LPS) O antigen (O-Ag). Three genes, flmB-neuA-flmD, were found to be interrupted by the transposon insertions; additionally, two other genes, one lying upstream (flmA) and one downstream (neuB), were found to be clustered in the same operon. While the flmA and flmB genes were present in all mesophilic Aeromonas spp. (A. hydrophila, A. caviae, A. veronii bv. veronii, and A. veronii bv. sobria) tested, this was not the case for the neuA-flmD-neuB genes. Construction and characterization of flmB insertion mutants in five other mesophilic Aeromonas strains revealed the loss of motility, flagella, and adherence but did not alter the LPS composition of these strains. Taking the above findings into consideration, we conclude (i) that flagella and possibly the LPS O-Ag are involved in the adherence of the mesophilic Aeromonas to human epithelial cells; (ii) flmA and flmB are genes widely distributed in the mesophilic Aeromonas and are involved in flagella assembly, and thus adherence; and (iii) in A. caviae Sch3N the flmA and flmB genes are found in a putative operon together with neuA, flmD, and neuB and are involved in LPS O-Ag biosynthesis and probably have a role in flagellum assembly.
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