ArticleInfection and immunity2001
Staphylococcus aureus agr genotypes with enterotoxin production capabilities can resist neutrophil bactericidal activity.
Article in Infection and immunity, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 60 citations in OpenAlex.
- Staphylococcal mastitis in dairy cows.Frontiers in veterinary science · 2024Review
- Whole genome sequence-based analysis ofFrontiers in microbiology · 2023Article
- Phenotypic and genotypic virulence features of staphylococcal strains isolated from difficult-to-treat skin and soft tissue infections.PloS one · 2021Article
- Epidemiology and Classification of Mastitis.Animals : an open access journal from MDPI · 2020Review
- Association between the accessory gene regulator (agr) locus and the presence of superantigen genes in clinical isolates of methicillin-resistant Staphylococcus aureus.BMC research notes · 2019Article
- Changes in the agr locus affect enteritis caused by methicillin-resistant Staphylococcus aureus.Journal of clinical microbiology · 2009Article
- Changing trends in mastitis.Irish veterinary journal · 2009Article
- Differential abilities of capsulated and noncapsulated Staphylococcus aureus isolates from diverse agr groups to invade mammary epithelial cells.Infection and immunity · 2007Article
- Staphylococcus aureus enterotoxin D is secreted in milk and stimulates specific antibody responses in cows in the course of experimental intramammary infection.Infection and immunity · 2006Article
- Capsule-negative Staphylococcus aureus induces chronic experimental mastitis in mice.Infection and immunity · 2005Article
- Degradation of human antimicrobial peptide LL-37 by Staphylococcus aureus-derived proteinases.Antimicrobial agents and chemotherapy · 2004Article
- Comparative analysis of agr locus diversification and overall genetic variability among bovine and human Staphylococcus aureus isolates.Journal of clinical microbiology · 2004Article
- Molecular diagnostics of clinically important staphylococci.Folia microbiologica · 2004Review
- Prevalence of agr specificity groups among Staphylococcus aureus strains colonizing children and their guardians.Journal of clinical microbiology · 2003Article
- Analysis of the genetic variability of genes encoding the RNA III-activating components Agr and TRAP in a population of Staphylococcus aureus strains isolated from cows with mastitis.Journal of clinical microbiology · 2002Article
- Comparison of Staphylococcus aureus isolates from bovine and human skin, milking equipment, and bovine milk by phage typing, pulsed-field gel electrophoresis, and binary typing.Journal of clinical microbiology · 2002Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Staphylococcus aureus pathogenicity is mainly due to the production of a number of secreted and cell surface-associated proteins under the regulation of the agr gene. A region of the agr gene was used to subgroup S. aureus strains according to restriction fragment length polymorphisms. Additionally, strains were subtyped according to the coagulase gene in order to strengthen discriminatory power. Virulence capabilities of agr genotype subgroups were evaluated using an in vitro neutrophil bactericidal assay, which showed that prevalent genotypes were significantly better at evading this primary host defense. Multiplex PCR was then used to detect enterotoxin genes among the genotype subgroups in order to determine possible virulence candidates that enable strains to combat neutrophil killing. The prevalent genotype strains were found to possess higher production capabilities for enterotoxin A than did low-prevalence strains. The significance of enterotoxin A production capabilities in affecting pathogenicity of S. aureus strains was evaluated and found to have a profound effect on neutrophil killing abilities. The use of a large epidemiological database as a tool for subgrouping strains with varying degrees of pathogenicity has allowed the identification of relevant and previously undefined virulence factors that affect a pathogen's capability to overcome host immune defenses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.