Evidence map›Paper›PMID 11119458›Full record

ArticleHeart (British Cardiac Society)2001

Comparative accuracy of cardiovascular risk prediction methods in primary care patients.

A F Jones, J Walker, C Jewkes, F L Game, W A Bartlett, T Marshall, G R Bayly

Abstract readComparative Study
In one paragraph

Article in Heart (British Cardiac Society), 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

A F JonesDepartment of Clinical Biochemistry, Birmingham Heartlands and Solihull NHS Trust, Birmingham B9 5SS, UK. JonesAla@heartsol.wmids.nhs.uk
J Walker
C Jewkes
F L Game
W A Bartlett
T Marshall
G R Bayly

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo compare the relative accuracy of cardiovascular disease risk prediction methods based on equations derived from the Framingham heart study.

designRisk factor data were collected prospectively from subjects being evaluated by their primary care physicians for prevention of cardiovascular disease. Projected cardiovascular risks were calculated for each patient with the Framingham equations, and also estimated from the risk tables and charts based on the same equations.

setting12 primary care practices (46 doctors) in Birmingham. PATIENTS: 691 subjects aged 30-70 years.

main outcome measuresSensitivity, specificity, and positive and negative predictive values of the Framingham based risk tables and charts for treatment thresholds based on projected cardiovascular disease or coronary heart disease risk.

results59 subjects (8.5%) had projected 10 year coronary heart disease risks >/= 30%, and 291 (42.1%) had risks >/= 15%. At equivalent projected risk levels (10 year coronary heart disease >/= 30% and five year cardiovascular disease >/= 20%), the original Sheffield tables and those from New Zealand have the same sensitivities (40.0%, 95% confidence interval (CI) 26.6% to 57.8% v 41.2%, 95% CI 28.7% to 57. 3%) and specificities (98.6%, 95% CI 97.2% to 99.3% v 99.7%, 95% CI 98.8% to 100%). Modifications to the Sheffield tables improve sensitivity (91.4%, 95% CI 81.3% to 96.9%) but reduce specificity (95.8%, 95% CI 93.9% to 97.3%). The revised joint British recommendations' charts have high specificity (98.7%, 95% CI 97.5% to 99.5%) and good sensitivity (84.7%, 95% CI 71.0% to 93.0%).

conclusionsThe revised joint British recommendations charts appear to have the best combination of sensitivity and specificity for use in primary care patients.

Indexed as

Risk AssessmentAdultAgedCardiovascular DiseasesComorbidityDiabetes MellitusFemaleHumansHypercholesterolemiaHypertensionMaleMiddle AgedPredictive Value of TestsPrimary Health CareProspective StudiesRisk Factors

Identifiers

PMID11119458
PMCPMC1729574

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.