ArticleThe EMBO journal2000
Evolutionary dynamics of full genome content in Escherichia coli.
Article in The EMBO journal, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
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Who cites it
65 citing papers in PubMed.
- InspectorORF: a tool for visualizing Ribo-Seq and additional genomic or transcriptomic data.Bioinformatics advances · 2026Article
- Challenges and Opportunities in Analyzing Cancer-Associated Microbiomes.Cancer research · 2025Review
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- The microbial ecology of Escherichia coli in the vertebrate gut.FEMS microbiology reviews · 2022Review
- Molecular insights into the genome dynamics and interactions between core and acquired genomes ofProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Comparative Analysis of Tools and Approaches for Source TrackingFrontiers in microbiology · 2019Article
- Metabolic Determinants of Enzyme Evolution in a Genome-Scale Bacterial Metabolic Network.Genome biology and evolution · 2018Article
- Evolutionary and Functional Relationships of the dha Regulon by Genomic Context Analysis.PloS one · 2016Article
- Inter-individual differences in the gene content of human gut bacterial species.Genome biology · 2015Article
- Two rep genes in small cryptic plasmid pKST21 of Escherichia coli.Current microbiology · 2013Article
- Evolution of variation in presence and absence of genes in bacterial pathways.BMC evolutionary biology · 2012Article
- Vaginal microbiome: rethinking health and disease.Annual review of microbiology · 2012Review
- A quantitative account of genomic island acquisitions in prokaryotes.BMC genomics · 2011Article
- Survival of Escherichia coli in the environment: fundamental and public health aspects.The ISME journal · 2011Review
- Article
- Conditions for the evolution of gene clusters in bacterial genomes.PLoS computational biology · 2010Article
- Horizontal gene transfer of the secretome drives the evolution of bacterial cooperation and virulence.Current biology : CB · 2009Article
- Evolutionary constraints permeate large metabolic networks.BMC evolutionary biology · 2009Article
- Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The evolutionary history of the entire Escherichia coli chromosome was traced by examining the distribution of the approximately 4300 open reading frames (ORFs) from E.coli MG1655 among strains of known genealogical relationships. Using this framework to deduce the incidence of gene transfer and gene loss, a total of 67 events-37 additions and 30 deletions-were required to account for the distribution of all genes now present in the MG1655 chromosome. Nearly 90% of the ORFs were common to all strains examined, but, given the variation in gene content and chromosome size, strains can contain well over a megabase of unique DNA, conferring traits that distinguish them from other members of the species. Moreover, strains vary widely in their frequencies of deletions, which probably accounts for the variation in genome size within the species.
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