ArticleGenome research2000
A large database of chicken bursal ESTs as a resource for the analysis of vertebrate gene function.
Article in Genome research, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 88 citations in OpenAlex.
- B-lymphocyte tolerance and effector function in immunity and autoimmunity.Immunologic research · 2013Review
- Article
- Advanced technologies for genomic analysis in farm animals and its application for QTL mapping.Genetica · 2009Review
- Ocular expression of avian thymic hormone: changes during the recovery from induced myopia.Molecular vision · 2009Article
- Transcriptional profiling reveals a possible role for the timing of the inflammatory response in determining susceptibility to a viral infection.Journal of virology · 2006Article
- The leukocyte receptor complex in chicken is characterized by massive expansion and diversification of immunoglobulin-like Loci.PLoS genetics · 2006Article
- Avian models with spontaneous autoimmune diseases.Advances in immunology · 2006Review
- Expressed sequence tag analysis of Eimeria-stimulated intestinal intraepithelial lymphocytes in chickens.Molecular biotechnology · 2005Article
- Development of a cDNA array for chicken gene expression analysis.BMC genomics · 2005Article
- Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis.Genome biology · 2005Article
- Evaluation of the chicken transcriptome by SAGE of B cells and the DT40 cell line.BMC genomics · 2004Article
- FunnyBase: a systems level functional annotation of Fundulus ESTs for the analysis of gene expression.BMC genomics · 2004Article
- Development of a gene-based radiation hybrid map of chicken Chromosome 7 and comparison to human and mouse.Mammalian genome : official journal of the International Mammalian Genome Society · 2004Article
- A radiation hybrid map of chicken Chromosome 4.Mammalian genome : official journal of the International Mammalian Genome Society · 2004Article
- Cloning and functional characterisation of avian transcription factor E2A.BMC immunology · 2004Article
- In-silico identification of chicken immune-related genes.Immunogenetics · 2004Article
- Article
- Functional genomics in chickens: development of integrated-systems microarrays for transcriptional profiling and discovery of regulatory pathways.Comparative and functional genomics · 2004Article
- Insight into lymphoid development by gene expression profiling of avian B cells.Immunogenetics · 2003Article
- Functional genomic analysis reveals distinct neoplastic phenotypes associated with c-myb mutation in the bursa of Fabricius.Oncogene · 2003Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chicken B cells create their immunoglobulin repertoire within the Bursa of Fabricius by gene conversion. The high homologous recombination activity is shared by the bursal B-cell-derived DT40 cell line, which integrates transfected DNA constructs at high rates into its endogenous loci. Targeted integration in DT40 is used frequently to analyze the function of genes by gene disruption. In this paper, we describe a large database of >7000 expressed sequence tags (ESTs) from bursal lymphocytes that should be a valuable resource for the identification of gene disruption targets in DT40. ESTs of interest can be recognized easily by online or keyword searches. Because the database reflects the gene expression profile of bursal lymphocytes, it provides valuable hints as to which genes might be involved in B-cell-specific processes related to immunoglobulin repertoire formation, signal transduction, transcription, and apoptosis. This large collection of chicken ESTs will also be useful for gene expression studies and comparative gene mapping within the chicken genome project. Details of the bursal EST sequencing project and access to database search forms can be found on the DT40 web site (http://genetics.hpi.uni-hamburg.de/dt40.html).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.