ArticleJournal of bacteriology2001
Secreted euryarchaeal microhalocins kill hyperthermophilic crenarchaea.
Article in Journal of bacteriology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 40 citations in OpenAlex.
- Halocins and CMarine drugs · 2024Review
- Purification and Characterization of a New Halocin HA4 from Haloferax larsenii HA4 Isolated from a Salt Lake.Probiotics and antimicrobial proteins · 2021Article
- Isolation, characterization and exploring biotechnological potential of halophilic archaea from salterns of western India.3 Biotech · 2018Article
- Untapped Resources: Biotechnological Potential of Peptides and Secondary Metabolites in Archaea.Archaea (Vancouver, B.C.) · 2015Review
- Diversity and subcellular distribution of archaeal secreted proteins.Frontiers in microbiology · 2012Article
- The sulfolobicin genes of Sulfolobus acidocaldarius encode novel antimicrobial proteins.Journal of bacteriology · 2011Article
- A protein important for antimicrobial peptide resistance, YdeI/OmdA, is in the periplasm and interacts with OmpD/NmpC.Journal of bacteriology · 2009Article
- Growth kinetics of extremely halophilic archaea (family halobacteriaceae) as revealed by arrhenius plots.Journal of bacteriology · 2005Article
- Mercury inactivates transcription and the generalized transcription factor TFB in the archaeon Sulfolobus solfataricus.Antimicrobial agents and chemotherapy · 2004Article
- Purification and biological characterization of halocin C8, a novel peptide antibiotic from Halobacterium strain AS7092.Extremophiles : life under extreme conditions · 2003Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Few antibiotics targeting members of the archaeal domain are currently available for genetic studies. Since bacterial antibiotics are frequently directed against competing and related organisms, archaea by analogy might produce effective antiarchaeal antibiotics. Peptide antibiotic (halocin) preparations from euryarchaeal halophilic strains S8a, GN101, and TuA4 were found to be toxic for members of the hyperthermophilic crenarchaeal genus Sulfolobus. No toxicity was evident against representative bacteria or eukarya. Halocin S8 (strain S8a) and halocin R1 (strain GN101) preparations were cytostatic, while halocin A4 (strain TuA4) preparations were cytocidal. Subsequent studies focused on the use of halocin A4 preparations and Sulfolobus solfataricus. Strain TuA4 cell lysates were not toxic for S. solfataricus, and protease (but not nuclease) treatment of the halocin A4 preparation inactivated toxicity, indicating that the A4 toxic factor must be a secreted protein. Potassium chloride supplementation of the Sulfolobus assay medium potentiated toxicity, implicating use of a salt-dependent mechanism. The utility of halocin A4 preparations for genetic manipulation of S. solfataricus was assessed through the isolation of UV-induced resistant mutants. The mutants exhibited stable phenotypes and were placed into distinct classes based on their levels of resistance.
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