ArticleJournal of acquired immune deficiency syndromes (1999)2000
Association of severe insulin resistance with both loss of limb fat and elevated serum tumor necrosis factor receptor levels in HIV lipodystrophy.
Article in Journal of acquired immune deficiency syndromes (1999), 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 1 of them a synthesis that pooled it.
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Who cites it
61 citing papers in PubMed, 1 synthesis or guideline pooled it, 220 citations in OpenAlex.
- Pooled it
- Dipeptidyl peptidase IV inhibition does not adversely affect immune or virological status in HIV infected men and women: a pilot safety study.The Journal of clinical endocrinology and metabolism · 2013Trial
- Exercise training augments the peripheral insulin-sensitizing effects of pioglitazone in HIV-infected adults with insulin resistance and central adiposity.American journal of physiology. Endocrinology and metabolism · 2011Trial
- Down regulation of the inverse relationship between parathyroid hormone and irisin in male vitamin D-sufficient HIV patients.Journal of endocrinological investigation · 2023Article
- Duration of antiretroviral therapy among people living with HIV and incidence of hypertension in Ghana.Journal of clinical hypertension (Greenwich, Conn.) · 2020Article
- Endocrinological aspects of HIV infection.Journal of endocrinological investigation · 2018Review
- Abdominal fat depots, insulin resistance, and incident diabetes mellitus in women with and without HIV infection.AIDS (London, England) · 2018Article
- Factors Associated With Insulin Resistance in Adults With HIV Receiving Contemporary Antiretroviral Therapy: a Brief Update.Current HIV/AIDS reports · 2018Review
- Examining Relationships between Metabolism and Persistent Inflammation in HIV Patients on Antiretroviral Therapy.Mediators of inflammation · 2018Review
- Prevalence, Risk Factors, and Pathophysiology of Dysglycemia among People Living with HIV in Sub-Saharan Africa.Journal of diabetes research · 2018Review
- Immune reconstitution in ART treated, but not untreated HIV infection, is associated with abnormal beta cell function.PloS one · 2018Article
- Serious Non-AIDS Events: Therapeutic Targets of Immune Activation and Chronic Inflammation in HIV Infection.Drugs · 2016Review
- Adiponectin and interleukin-6, but not adipose tissue, are associated with worse neurocognitive function in HIV-infected men.Antiviral therapy · 2015Article
- Towards a mechanistic understanding of lipodystrophy and seipin functions.Bioscience reports · 2014Review
- Adipokines, hormones related to body composition, and insulin resistance in HIV fat redistribution syndrome.BMC infectious diseases · 2014Article
- The role of HIV and monocytes/macrophages in adipose tissue biology.Journal of acquired immune deficiency syndromes (1999) · 2014Article
- Associations of HIV infection with insulin and glucose levels in antiretroviral-naive Rwandan women: a cross-sectional analysis.BMJ open · 2013Article
- Chromium Therapy for Insulin Resistance Associated with HIV-Disease.Journal of AIDS & clinical research · 2013Article
- Lipodystrophy and inflammation predict later grip strength in HIV-infected men: the MACS Body Composition substudy.AIDS research and human retroviruses · 2013Article
- Peripheral fat loss and decline in adipogenesis in older humans.Metabolism: clinical and experimental · 2013Article
1 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
HIV-lipodystrophy (HIV-LD) is characterized by the loss of body fat from the limbs and face, an increase in truncal fat, insulin resistance, and hyperlipidemia, factors placing affected patients at increased risk for vascular disease. This study evaluated insulin sensitivity and inflammatory status associated with HIV-LD and provides suggestions about its etiology. Insulin sensitivity and immune activation markers were assessed in 12 control subjects and 2 HIV-positive groups, 14 without and 15 with LD syndrome. Peripheral insulin sensitivity (mostly skeletal muscle) was determined with the hyperinsulinemic-euglycemic clamp. Circulating insulin-like growth factor (IGF) binding protein-1 (IGFBP-1) and free fatty acid (FFA) levels, and their response to insulin infusion were indicative of insulin responsiveness of liver and adipose tissue, respectively. Serum levels of soluble type 2 tumor necrosis factor-alpha (TNF-alpha) receptor (sTNFR2) were used as an indicator of immune activation. HIV-LD study subjects had significantly reduced (twofold) peripheral insulin sensitivity, but normal levels of FFA and reduced levels of IGFBP-1, relative to the nonlipodystrophy groups, indicating that the loss of insulin sensitivity was more pronounced in skeletal muscle than in liver or fat. The significant loss of peripheral fat in the HIV-LD group (34%; p <.05) closely correlated with the reduced peripheral insulin sensitivity (p =. 0001). Levels of sTNFR2 were elevated in all HIV-infected study subjects, but they were significantly higher in those with lipodystrophy than without, and sTNFR2 levels strongly correlated with the reduction in insulin sensitivity (p =.0001). Loss of peripheral fat, normal levels of FFA, and reduced levels of IGFBP-1 indicate that insulin resistance in HIV-LD is distinct from type 2 diabetes and obesity. The relationship between the degree of insulin resistance and sTNFR2 levels suggests an inflammatory stimulus is contributing to the development of HIV-associated lipodystrophy.
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