ArticleOncogene2000
A role for FAK in the Concanavalin A-dependent secretion of matrix metalloproteinase-2 and -9.
Article in Oncogene, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 79 citations in OpenAlex.
- An exploratory analysis of disulfidptosis-related gene signatures in minimal change disease identifies metabolic and immune associations.Frontiers in cell and developmental biology · 2026Article
- Sanguinarine inhibits melanoma invasion and migration by targeting the FAK/PI3K/AKT/mTOR signalling pathway.Pharmaceutical biology · 2023Article
- Molecular Mechanisms of Proteinuria in Minimal Change Disease.Frontiers in medicine · 2021Review
- Regulation of drug resistance and metastasis of gastric cancer cells via the microRNA647-ANK2 axis.International journal of molecular medicine · 2018Article
- Role of miR-647 in human gastric cancer suppression.Oncology reports · 2017Article
- Role of Aquaporin 1 Signalling in Cancer Development and Progression.International journal of molecular sciences · 2017Review
- Focal Adhesion Kinase: Insight into Molecular Roles and Functions in Hepatocellular Carcinoma.International journal of molecular sciences · 2017Review
- Nifuroxazide induces apoptosis and impairs pulmonary metastasis in breast cancer model.Cell death & disease · 2015Article
- Knockdown of WAVE3 impairs HGF induced migration and invasion of prostate cancer cells.Cancer cell international · 2015Article
- Extracellular matrix protein laminin induces matrix metalloproteinase-9 in human breast cancer cell line mcf-7.Cancer microenvironment : official journal of the International Cancer Microenvironment Society · 2014Article
- Targeting focal adhesion turnover in invasive breast cancer cells by the purine derivative reversine.British journal of cancer · 2013Article
- Rab5 activation promotes focal adhesion disassembly, migration and invasiveness in tumor cells.Journal of cell science · 2013Article
- Effect of siRNA targeting MTA1 on metastasis malignant phenotype of ovarian cancer A2780 cells.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2013Article
- Article
- Dieckol from Ecklonia cava suppresses the migration and invasion of HT1080 cells by inhibiting the focal adhesion kinase pathway downstream of Rac1-ROS signaling.Molecules and cells · 2012Article
- Nobiletin, a citrus flavonoid, suppresses invasion and migration involving FAK/PI3K/Akt and small GTPase signals in human gastric adenocarcinoma AGS cells.Molecular and cellular biochemistry · 2011Article
- FAK is involved in invasion and metastasis of hepatocellular carcinoma.Clinical & experimental metastasis · 2010Article
- Studies on Multifunctional Effect of All-Trans Retinoic Acid (ATRA) on Matrix Metalloproteinase-2 (MMP-2) and Its Regulatory Molecules in Human Breast Cancer Cells (MCF-7).Journal of oncology · 2009Article
- The EphA2 receptor and ephrinA1 ligand in solid tumors: function and therapeutic targeting.Molecular cancer research : MCR · 2008Review
- Involvement of focal adhesion kinase in cellular invasion of head and neck squamous cell carcinomas via regulation of MMP-2 expression.British journal of cancer · 2008Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To study the signaling pathway critical for the secretion of matrix metalloproteinases (MMPs), we examined the role of focal adhesion kinase (FAK) in Concanavalin A (Con A)-stimulated cells. We established a cell line in which FAK gene was conditionally inducible by use of FAK-null fibroblasts and the tetracycline repression system. In this cell line, FAK expression was undetectable in the presence of tetracycline but induced within 1 day by the removal of the drug. We found that FAK expression augmented the Con A-dependent secretion of MMP-9 and MMP-2. In contrast, proteolytic activation of MMP-2 by Con A-treatment did not require FAK expression. In addition, activation of MMP-secretion and tyrosine phosphorylation of FAK by Con A, but not the proteolytic activation of MMP-2, required attachment of the cells to the extracellular matrix. Taken together, our results suggest that the FAK signaling pathway play a pivotal role in the secretion of MMPs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.