ArticleProceedings of the National Academy of Sciences of the United States of America2000
Functional redundancy of cryptochromes and classical photoreceptors for nonvisual ocular photoreception in mice.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
51 citing papers in PubMed, 191 citations in OpenAlex.
- Full-Length Cryptochrome 1 in the Outer Segments of the Retinal Blue Cone Photoreceptors in Humans and Great Apes Suggests a Role Beyond Transcriptional Repression.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Circadian clock disruption promotes retinal photoreceptor degeneration.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Light sampling behaviour regulates circadian entrainment in mice.BMC biology · 2024Article
- 2.4 GHz Electromagnetic Field Influences the Response of the Circadian Oscillator in the Colorectal Cancer Cell Line DLD1 to miR-34a-Mediated Regulation.International journal of molecular sciences · 2022Article
- The Effects of Light and the Circadian System on Rhythmic Brain Function.International journal of molecular sciences · 2022Review
- Localisation of cryptochrome 2 in the avian retina.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2022Article
- Cryptochromes in Mammals and Birds: Clock or Magnetic Compass?Physiology (Bethesda, Md.) · 2021Article
- Light entrainment of retinal biorhythms: cryptochrome 2 as candidate photoreceptor in mammals.Cellular and molecular life sciences : CMLS · 2020Article
- RNA Splicing Factor Mutations That Cause Retinitis Pigmentosa Result in Circadian Dysregulation.Journal of biological rhythms · 2020Article
- Ocular Clocks: Adapting Mechanisms for Eye Functions and Health.Investigative ophthalmology & visual science · 2018Review
- Differential roles for cryptochromes in the mammalian retinal clock.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2018Article
- A novel photic entrainment mechanism for the circadian clock in an insect: involvement ofZoological letters · 2018Article
- Cryptochrome Interacts With Actin and Enhances Eye-Mediated Light Sensitivity of the Circadian Clock inFrontiers in molecular neuroscience · 2018Article
- Animal Cryptochromes: Divergent Roles in Light Perception, Circadian Timekeeping and Beyond.Photochemistry and photobiology · 2017Review
- Effect of circadian clock gene mutations on nonvisual photoreception in the mouse.Investigative ophthalmology & visual science · 2012Article
- Epigenetic silencing of the circadian clock gene CRY1 is associated with an indolent clinical course in chronic lymphocytic leukemia.PloS one · 2012Article
- Regulation of nucleotide excision repair activity by transcriptional and post-transcriptional control of the XPA protein.Nucleic acids research · 2011Article
- Reduced light response of neuronal firing activity in the suprachiasmatic nucleus and optic nerve of cryptochrome-deficient mice.PloS one · 2011Article
- Searching for a photocycle of the cryptochrome photoreceptors.Current opinion in plant biology · 2010Review
- Intrinsically photosensitive retinal ganglion cells.Physiological reviews · 2010Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The daily light-dark (LD) cycle exerts a powerful influence on the temporal organization of behavior and physiology. Much of this influence is preserved in behaviorally blind retinally degenerate mice; the photoreceptors underlying this nonvisual phototransduction are unknown. The mammalian eye contains at least two classes of photoactive pigments, the vitamin A-based opsins and the vitamin B(2)-based cryptochromes. To genetically define the roles of these pigments in light modulation of behavior, we generated rd/rd;mCry1(-)/mCry1(-);mCry2(-)/mCry2(-) mutant mice lacking rods and most cones as well as both cryptochrome proteins. The response of the mutant mouse to photic input was analyzed at both behavioral and molecular levels. Behaviorally, mice lacking either classical photoreceptors or cryptochromes exhibited strongly rhythmic locomotor responses to 10 and 100 lux daily LD 12 h/12-h cycles; however, triple mutant mice carrying both cryptochrome and retinal degenerate mutations were nearly arrhythmic under both LD cycles and in constant darkness. At the molecular level, the light induction of c-fos transcription in the suprachiasmatic nucleus was markedly reduced in the triple mutant mouse compared with either rd/rd or cryptochrome mutant mice. These data indicate that classical opsins and cryptochromes serve functionally redundant roles in the transduction of light information to behavioral modulation and suggest a pleomorphic role for cryptochromes in both photoreception and central clock mechanism.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.