ArticleProceedings of the National Academy of Sciences of the United States of America2000
Identification of XPR-1, a progesterone receptor required for Xenopus oocyte activation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.
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Who cites it
49 citing papers in PubMed, 1 synthesis or guideline pooled it, 166 citations in OpenAlex.
- Vaginal progesterone in women with an asymptomatic sonographic short cervix in the midtrimester decreases preterm delivery and neonatal morbidity: a systematic review and metaanalysis of individual patient data.American journal of obstetrics and gynecology · 2012Pooled it
- Establishment of a graphene quantum dot (GQD) based steroid binding assay for the nuclear progesterone receptor (pgr).Biochemistry and biophysics reports · 2024Article
- Article
- Membrane progesterone receptor induces meiosis in Xenopus oocytes through endocytosis into signaling endosomes and interaction with APPL1 and Akt2.PLoS biology · 2020Article
- Impaired oocyte maturation and ovulation in membrane progestin receptor (mPR) knockouts in zebrafish.Molecular and cellular endocrinology · 2020Article
- Review
- The G2-to-M transition from a phosphatase perspective: a new vision of the meiotic division.Cell division · 2020Review
- Mutual action by Gγ and Gβ for optimal activation of GIRK channels in a channel subunit-specific manner.Scientific reports · 2019Article
- Brief Local Application of Progesterone via a Wearable Bioreactor Induces Long-Term Regenerative Response in Adult Xenopus Hindlimb.Cell reports · 2018Article
- Cloning and olfactory expression of progestin receptors in the Chinese black sleeper Bostrichthys sinensis.General and comparative endocrinology · 2016Article
- Nuclear progestin receptor (pgr) knockouts in zebrafish demonstrate role for pgr in ovulation but not in rapid non-genomic steroid mediated meiosis resumption.Frontiers in endocrinology · 2015Article
- Transmembrane signal transduction in oocyte maturation and fertilization: focusing on Xenopus laevis as a model animal.International journal of molecular sciences · 2014Review
- G protein-coupled receptors: extranuclear mediators for the non-genomic actions of steroids.International journal of molecular sciences · 2014Review
- Article
- Membrane progestin receptors in the midbrain ventral tegmental area are required for progesterone-facilitated lordosis of rats.Hormones and behavior · 2013Article
- The effects of progesterone on oocyte maturation and embryo development.International journal of fertility & sterility · 2013Review
- The classical progesterone receptor mediates the rapid reduction of fallopian tube ciliary beat frequency by progesterone.Reproductive biology and endocrinology : RB&E · 2013Article
- A truncated progesterone receptor (PR-M) localizes to the mitochondrion and controls cellular respiration.Molecular endocrinology (Baltimore, Md.) · 2013Article
- Xenopus oocyte meiosis lacks spindle assembly checkpoint control.The Journal of cell biology · 2013Article
- Water homeostasis in the fish oocyte: new insights into the role and molecular regulation of a teleost-specific aquaporin.Fish physiology and biochemistry · 2013Review
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4 authors at 1 institution in 1 country.
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Abstract
Quiescent full-grown Xenopus oocytes remain arrested at the G(2)/M border of meiosis I until exposed to progesterone, their natural mitogen. Progesterone triggers rapid, nontranscriptional responses that lead to the translational activation of stored mRNAs, resumption of the meiotic cell cycles, and maturation of the oocyte into a fertilizable egg. It has long been presumed that progesterone activates the oocyte through a novel nontranscriptional signaling receptor. Here, we provide evidence that a conventional transcriptional progesterone receptor cloned from Xenopus oocytes, XPR-1, is required for oocyte activation. Overexpression of XPR-1 through mRNA injection increases sensitivity to progesterone and accelerates progesterone-activated cell cycle reentry. Injection of XPR-1 antisense oligonucleotides blocks the ability of oocytes to respond to progesterone; these oocytes are rescued by subsequent injection of XPR-1 or the human progesterone receptor PR-B. Antisense-treated oocytes can be activated in response to inhibition of protein kinase A, one of the earliest known changes occurring downstream of progesterone stimulation. These results argue that the conventional progesterone receptor also functions as the signaling receptor that is responsible for the rapid nontranscriptional activation of frog oocytes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.