ArticleAmerican journal of human genetics2001
Population structure in admixed populations: effect of admixture dynamics on the pattern of linkage disequilibrium.
Article in American journal of human genetics, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00005335 (Genetic Epidemiology of Lipoprotein-Lipid Levels), which is not on this map. Cited by 118 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Genetic Epidemiology of Lipoprotein-Lipid Levels
Who cites it
118 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Detecting fitness epistasis in recently admixed populations with genome-wide data.BMC genomics · 2020Pooled it
- Genomic evidence for shared common ancestry of East African hunting-gathering populations and insights into local adaptation.Proceedings of the National Academy of Sciences of the United States of America · 2019Trial
- AdmixLD: fast genome-scale inference of ancestry disequilibrium in hybrid zones.Bioinformatics (Oxford, England) · 2026Article
- Interpreting SNP heritability in admixed populations.Genetics · 2025Article
- Anthropogenic Hybridization Contributes to the Naturalization of Introduced Domestic Mallards (Ecology and evolution · 2025Article
- Interpreting SNP heritability in admixed populations.bioRxiv : the preprint server for biology · 2025Article
- Genetic Diversity Analysis and Prediction of Potential Suitable Areas for the Rare and Endangered Wild PlantPlants (Basel, Switzerland) · 2024Article
- Interpreting population- and family-based genome-wide association studies in the presence of confounding.PLoS biology · 2024Article
- Global and Local Ancestry and its Importance: A Review.Current genomics · 2024Review
- Reduced gene flow and bottleneck in the threatened giant armadillo (Priodontes maximus): implications for its conservation.Genetics and molecular biology · 2024Article
- Impact of population structure in the estimation of recent historical effective population size by the software GONE.Genetics, selection, evolution : GSE · 2023Article
- Polygenic prediction across populations is influenced by ancestry, genetic architecture, and methodology.Cell genomics · 2023Article
- Strategies for the Genomic Analysis of Admixed Populations.Annual review of biomedical data science · 2023Review
- Comprehensive analysis of geographic and breed-purpose influences on genetic diversity and inherited disease risk in the Doberman dog breed.Canine medicine and genetics · 2023Article
- Interpreting population and family-based genome-wide association studies in the presence of confounding.bioRxiv : the preprint server for biology · 2023Article
- Population genomics of American mink using genotype data.Frontiers in genetics · 2023Article
- Country-wide genetic monitoring over 21 years reveals lag in genetic recovery despite spatial connectivity in an expanding carnivore (Eurasian otter,Evolutionary applications · 2022Article
- Demographic history differences between Hispanics and Brazilians imprint haplotype features.G3 (Bethesda, Md.) · 2022Article
- Human genetic admixture through the lens of population genomics.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- Patterns and Causes of Signed Linkage Disequilibria in Flies and Plants.Molecular biology and evolution · 2021Article
58 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors.
Funding
Abstract
Gene flow between genetically distinct populations creates linkage disequilibrium (admixture linkage disequilibrium [ALD]) among all loci (linked and unlinked) that have different allele frequencies in the founding populations. We have explored the distribution of ALD by using computer simulation of two extreme models of admixture: the hybrid-isolation (HI) model, in which admixture occurs in a single generation, and the continuous-gene-flow (CGF) model, in which admixture occurs at a steady rate in every generation. Linkage disequilibrium patterns in African American population samples from Jackson, MS, and from coastal South Carolina resemble patterns observed in the simulated CGF populations, in two respects. First, significant association between two loci (FY and AT3) separated by 22 cM was detected in both samples. The retention of ALD over relatively large (>10 cM) chromosomal segments is characteristic of a CGF pattern of admixture but not of an HI pattern. Second, significant associations were also detected between many pairs of unlinked loci, as observed in the CGF simulation results but not in the simulated HI populations. Such a high rate of association between unlinked markers in these populations could result in false-positive linkage signals in an admixture-mapping study. However, we demonstrate that by conditioning on parental admixture, we can distinguish between true linkage and association resulting from shared ancestry. Therefore, populations with a CGF history of admixture not only are appropriate for admixture mapping but also have greater power for detection of linkage disequilibrium over large chromosomal regions than do populations that have experienced a pattern of admixture more similar to the HI model, if methods are employed that detect and adjust for disequilibrium caused by continuous admixture.
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