ReviewMolecular and cellular biochemistry2000
Mechanisms of transcriptional activation of cAMP-responsive element-binding protein CREB.
Review in Molecular and cellular biochemistry, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 67 citations in OpenAlex.
- Association between interleukin-18 polymorphisms and systemic lupus erythematosus: a meta-analysis.Molecular biology reports · 2013Pooled it
- Association of IL-18 polymorphisms with rheumatoid arthritis and systemic lupus erythematosus in Asian populations: a meta-analysis.BMC medical genetics · 2012Pooled it
- Interleukin-18 promoter polymorphism and asthma risk: a meta-analysis.Molecular biology reports · 2012Pooled it
- The CREM-IL-15 axis: decoding the persistence-exhaustion paradox in NK cell immunotherapy.Cancer immunology, immunotherapy : CII · 2026Review
- Integration of cAMP and TRPV4 Signaling to Optimize Collagen Remodeling for Management of Fibrosis.Cells · 2025Review
- Lipolysis regulates major transcriptional programs in brown adipocytes.Nature communications · 2022Article
- Procyanidins and Alzheimer's Disease.Molecular neurobiology · 2019Review
- Structural Basis for Graded Inhibition of CREB:DNA Interactions by Multisite Phosphorylation.Biochemistry · 2018Article
- Niclosamide suppresses acute myeloid leukemia cell proliferation through inhibition of CREB-dependent signaling pathways.Oncotarget · 2018Article
- Dibutyryl-cAMP attenuates pulmonary fibrosis by blocking myofibroblast differentiation via PKA/CREB/CBP signaling in rats with silicosis.Respiratory research · 2017Article
- CREB modulates calcium signaling in cAMP-induced bone marrow stromal cells (BMSCs).Cell calcium · 2014Article
- Genetic polymorphism of interleukin-18 gene promoter region in rheumatoid arthritis patients from southern India.Journal of clinical and diagnostic research : JCDR · 2014Article
- Differential expression of the melanocortin-4 receptor in male and female C57BL/6J mice.Molecular biology reports · 2014Article
- Interleukin 18 gene polymorphism is a risk factor for multiple sclerosis.Molecular biology reports · 2014Article
- Transcription factors in heart: promising therapeutic targets in cardiac hypertrophy.Current cardiology reviews · 2011Review
- Lack of cAMP-response element-binding protein 1 in the hypothalamus causes obesity.The Journal of biological chemistry · 2011Article
- Transcriptional repression and DNA looping associated with a novel regulatory element in the final exon of the lymphotoxin-β gene.Genes and immunity · 2011Article
- Characterization of promoter elements regulating the expression of the human neurotensin/neuromedin N gene.The Journal of biological chemistry · 2011Article
- Regulation of aldosterone synthase by activator transcription factor/cAMP response element-binding protein family members.Endocrinology · 2010Article
- Interleukin-18 gene 105A/C genetic polymorphism is associated with the susceptibility of Kawasaki disease.Journal of clinical laboratory analysis · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The CREB-CREM transcription factors are the main gene regulatory effectors of the cAMP signaling pathway. The investigations of this family of transcription factors had a profound impact on the understanding of signaling-induced gene transcription. Here we discuss some key aspects of the underlying biology, review transcriptional activation by CREB proteins through transcription cofactors and present novel insights into the context- and position-specific function of CREB on complex genes.
Indexed as
Identifiers
11108130W2115351711What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.