ArticleImmunology2000
An alphabeta T-cell-independent immunoprotective response towards gut coccidia is supported by gammadelta cells.
Article in Immunology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 56 citations in OpenAlex.
- Characterization of Bovine Intraepithelial T Lymphocytes in the Gut.Pathogens (Basel, Switzerland) · 2023Article
- Effect of combined in ovo administration of zinc glycine chelate (Zn-Gly) and a multistrain probiotic on the modulation of cellular and humoral immune responses in broiler chickens.Poultry science · 2023Article
- Article
- Mitochondria maintain controlled activation state of epithelial-resident T lymphocytes.Science immunology · 2018Article
- Policing the intestinal epithelial barrier: Innate immune functions of intraepithelial lymphocytes.Current pathobiology reports · 2018Article
- Contributions of Farm Animals to Immunology.Frontiers in veterinary science · 2018Review
- Dissecting the Genomic Architecture of Resistance toFrontiers in genetics · 2018Article
- Immunoregulation effects of different γδT cells and toll-like receptor signaling pathways in neonatal necrotizing enterocolitis.Medicine · 2017Article
- Intestinal Barrier Interactions with Specialized CD8 T Cells.Frontiers in immunology · 2017Review
- Intestinal intraepithelial lymphocyte activation promotes innate antiviral resistance.Nature communications · 2015Article
- γδ T cells confer protection against murine cytomegalovirus (MCMV).PLoS pathogens · 2015Article
- Coccidiosis: recent advancements in the immunobiology ofVeterinary medicine (Auckland, N.Z.) · 2014Review
- Six-of-the-best: unique contributions of γδ T cells to immunology.Nature reviews. Immunology · 2013Review
- T cell reactions of Eimeria bovis primary and challenge-infected calves.Parasitology research · 2010Article
- Porcine coccidiosis--investigations on the cellular immune response against Isospora suis.Parasitology research · 2009Review
- Gammadelta T lymphocytes: a new type of regulatory T cells suppressing murine 2,4,6-trinitrobenzene sulphonic acid (TNBS)-induced colitis.International journal of colorectal disease · 2008Article
- Human gamma delta T cells: candidates for the development of immunotherapeutic strategies.Immunologic research · 2007Review
- Porcine isosporosis: infection dynamics, pathophysiology and immunology of experimental infections.Wiener klinische Wochenschrift · 2007Review
- Intestinal intraepithelial lymphocytes sustain the epithelial barrier function against Eimeria vermiformis infection.Infection and immunity · 2006Article
- Age-dependent requirement for gammadelta T cells in the primary but not secondary protective immune response against an intestinal parasite.The Journal of experimental medicine · 2003Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Although gammadelta cells are commonly hypothesized to provide a 'first line of defence', gammadelta-cell-deficient mice are generally only marginally more susceptible to pathogens. Because gammadelta cells are enriched within epithelia, it is important to resolve whether immunoprotective capacity towards epithelial-tropic pathogens is absent from the gammadelta-cell compartment, or whether such activity is present but simply redundant with that of alphabeta T cells. In this work, following infection of the intestinal epithelium of alphabeta T-cell-deficient mice with the coccidian parasite, Eimeria vermiformis, gammadelta cells were shown to support the rapid activation of other lymphoid cells and to confer a transferable antipathogen effect that could be eradicated by neutralization of interferon-gamma. However, unlike alphabeta T cells, these effects of gammadelta cells showed no evidence of functional immunological memory. These results are directly relevant to coccidiosis, an economically significant disease of livestock, and should have general relevance to infections involving alphabeta T-cell deficiencies, e.g. cryptosporidiosis in patients with acquired immune deficiency syndrome (AIDS).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.