ArticleBiophysical journal2000
The effects of non-identifiability on testing for detailed balance in aggregated Markov models for ion-channel gating.
Article in Biophysical journal, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Using independent open-to-closed transitions to simplify aggregated Markov models of ion channel gating kinetics.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
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Abstract
Aggregated Markov models are a widely used tool to model patch clamp data measured from single ion channels. These channels must obey the principle of detailed balance in thermodynamic equilibrium; otherwise, the channel is driven by an external source of energy. We investigate the power of a likelihood ratio test for detailed balance for a number of data points which is in the order of magnitude of patch clamp experiments. We show that for certain models with nearly equal dwell times, a test for detailed balance suffers from a loss of power to detect violations of detailed balance which is due to the non-identifiability of the transition rates for models with equal dwell times.
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