ArticleThe American journal of pathology2000
Intracerebral recruitment and maturation of dendritic cells in the onset and progression of experimental autoimmune encephalomyelitis.
Article in The American journal of pathology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers.
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Who cites it
80 citing papers in PubMed, 248 citations in OpenAlex.
- Anti-LGI1 encephalitis and Langerhans cell histiocytosis: Two associated entities? A case report.Heliyon · 2024Article
- Choroid plexus-selective inactivation of adenosine AJournal of neuroinflammation · 2022Article
- The role of type I IFN in autoimmune and autoinflammatory diseases with CNS involvement.Frontiers in neurology · 2022Review
- Article
- Age‑dependent alterations in the immunoreactivity of macrophage inflammatory protein‑3α and its receptor CCR6 in the gerbil hippocampus.Molecular medicine reports · 2020Article
- Antigen-presenting cell diversity for T cell reactivation in central nervous system autoimmunity.Journal of molecular medicine (Berlin, Germany) · 2018Review
- Time-Course Changes and New Expressions of MIP-3α and Its Receptor, CCR6, in the Gerbil Hippocampal CA1 Area Following Transient Global Cerebral Ischemia.Neurochemical research · 2018Article
- FDC:TFH Interactions within Cervical Lymph Nodes of SIV-Infected Rhesus Macaques.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2018Article
- Targeting DEC-205Molecular medicine (Cambridge, Mass.) · 2018Article
- To the Brain and Back: Migratory Paths of Dendritic Cells in Multiple Sclerosis.Journal of neuropathology and experimental neurology · 2018Review
- Follicular Dendritic Cells of Lymph Nodes as Human Immunodeficiency Virus/Simian Immunodeficiency Virus Reservoirs and Insights on Cervical Lymph Node.Frontiers in immunology · 2018Review
- The meningeal and choroidal infiltration routes for leukocytes in stroke.Therapeutic advances in neurological disorders · 2018Review
- CCR7 deficient inflammatory Dendritic Cells are retained in the Central Nervous System.Scientific reports · 2017Article
- Dendritic cells as therapeutic targets in neuroinflammation.Cellular and molecular life sciences : CMLS · 2016Review
- Cutting Edge: CD99 Is a Novel Therapeutic Target for Control of T Cell-Mediated Central Nervous System Autoimmune Disease.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Live Imaging of Immune Responses in Experimental Models of Multiple Sclerosis.Frontiers in immunology · 2016Review
- Advancing drug delivery systems for the treatment of multiple sclerosis.Immunologic research · 2015Review
- Interleukin-36γ is expressed by neutrophils and can activate microglia, but has no role in experimental autoimmune encephalomyelitis.Journal of neuroinflammation · 2015Article
- Focal transient CNS vessel leak provides a tissue niche for sequential immune cell accumulation during the asymptomatic phase of EAE induction.Experimental neurology · 2015Article
- A single infection with Chlamydia pneumoniae is sufficient to exacerbate atherosclerosis in ApoE deficient mice.Cellular immunology · 2015Article
20 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dendritic cells (DCs) are thought to be key elements in the initiation and maintenance of autoimmune diseases. In this study, we sought evidence that DCs recruited to the central nervous system (CNS), a site that is primarily devoid of resident DCs, play a role in the effector phase and propagation of the immune response in experimental autoimmune encephalomyelitis (EAE). After immunization of SJL mice with proteolipid protein 139-151 peptide, process-bearing cells expressing the DC markers DEC-205 and CD11c appeared early in the spinal cord. During acute, chronic, and relapsing EAE, DEC-205(+) DCs expressing a lymphostimulatory phenotype (including the mature DC marker MIDC-8, major histocompatibility complex class II, CD40, and CD86 molecules) accumulated within the CNS inflammatory cell infiltrates. More prominent infiltration of the spinal cord parenchyma by mature DCs was observed in mice with relapsing disease. Macrophage inflammatory protein 3alpha, a chemokine active on DCs and lymphocytes, and its receptor CCR6 were up-regulated in the CNS during EAE. These findings suggest that intracerebral recruitment and maturation of DCs may be crucial in the local stimulation and maintenance of autoreactive immune responses, and that therapeutic strategies aimed at manipulating DC migration could be useful in the treatment of CNS autoimmune disorders.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.