ArticleThe American journal of pathology2000
Facilitated wound healing by activation of the Transglutaminase 1 gene.
Article in The American journal of pathology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 51 citations in OpenAlex.
- Gapmer Antisense Oligonucleotide Targeting E-Cadherin Rescues Abnormal Keratinization in X-Linked Ichthyosis Models.Biomolecules & therapeutics · 2026Article
- ECM-Focused Proteomic Analysis of Ear Punch Regeneration inJournal of proteome research · 2025Article
- Transglutaminase 1: Emerging Functions beyond Skin.International journal of molecular sciences · 2024Review
- Environmental pro-oxidants induce altered envelope protein profiles in human keratinocytes.Toxicological sciences : an official journal of the Society of Toxicology · 2023Article
- Review
- Review
- Skin remodeling and wound healing in the Gottingen minipig following exposure to sulfur mustard.Experimental and molecular pathology · 2020Article
- Clumping factor B is an important virulence factor during Staphylococcus aureus skin infection and a promising vaccine target.PLoS pathogens · 2019Article
- Article
- Transglutaminase 2 regulates osteoclast differentiation via a Blimp1-dependent pathway.Scientific reports · 2017Article
- Expression of Transglutaminase in Foreskin of Children with Balanitis Xerotica Obliterans.International journal of molecular sciences · 2016Article
- Evidence of the survival of ectopically transplanted oral mucosal epithelial stem cells after repeated wounding of cornea.Molecular therapy : the journal of the American Society of Gene Therapy · 2014Article
- Epidermal transglutaminase (TGase 3) is required for proper hair development, but not the formation of the epidermal barrier.PloS one · 2012Article
- E-cadherin and transglutaminase-1 epithelial barrier restoration precedes type IV collagen basement membrane reconstruction following vocal fold mucosal injury.Cells, tissues, organs · 2011Article
- Exocytosis of acid sphingomyelinase by wounded cells promotes endocytosis and plasma membrane repair.The Journal of cell biology · 2010Article
- Transcriptome profiles of carcinoma-in-situ and invasive non-small cell lung cancer as revealed by SAGE.PloS one · 2010Article
- Transglutaminases, involucrin, and loricrin as markers of epidermal differentiation in skin substitutes derived from human sweat gland cells.Pediatric surgery international · 2010Article
- Transglutaminase-1 regulates renal epithelial cell proliferation through activation of Stat-3.The Journal of biological chemistry · 2009Article
- Expression and regulation of cornified envelope proteins in human corneal epithelium.Investigative ophthalmology & visual science · 2006Article
- Wound-healing studies in transgenic and knockout mice.Molecular biotechnology · 2004Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transglutaminase 1 (TGase 1) is a Ca(2+)-dependent enzyme which catalyzes epsilon-(gamma-glutamyl)lysine cross-linking of substrate proteins such as involucrin and loricrin to generate the cornified envelope at the cell periphery of the stratum corneum. We have shown that disruption of the TGase 1 gene in mice results in neonatal lethality, absence of the cornified envelope, and impaired skin barrier function. Based on the importance of TGase 1 in epidermal morphogenesis, we have now assessed its role in wound healing. In neonatal mouse skin, TGase 1 mRNA as well as keratin 6alpha was induced in the epidermis at the wound edges as early as 2 hours after injury and that expression continued in the migrating epidermis until completion of re-epithelialization. The TGase 1 enzyme co-localized on the plasma membrane of migrating keratinocytes with involucrin, but not with loricrin, which suggests the premature assembly of the cornified envelope. Similar injuries to TGase 1 knockout mouse skins grafted on athymic nude mice showed substantial delays in wound healing concomitant with sustained K6alpha mRNA induction. From these results, we suggest that activation of the TGase 1gene is essential for facilitated repair of skin injury.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.