ArticleThe American journal of pathology2000
Up-regulation of CCR5 expression in the placenta is associated with human immunodeficiency virus-1 vertical transmission.
Article in The American journal of pathology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 50 citations in OpenAlex.
- Gestational Viral Infections: Role of Host Immune System.Microorganisms · 2023Review
- Placental Immune Responses to Viruses: Molecular and Histo-Pathologic Perspectives.International journal of molecular sciences · 2021Review
- Placental Macrophage (Hofbauer Cell) Responses to Infection During Pregnancy: A Systematic Scoping Review.Frontiers in immunology · 2021Article
- Mother-to-Child HIV Transmission Bottleneck Selects for Consensus Virus with Lower Gag-Protease-Driven Replication Capacity.Journal of virology · 2017Article
- Impact of HIV-1 infection on the feto-maternal crosstalk and consequences for pregnancy outcome and infant health.Seminars in immunopathology · 2016Review
- Analysis of multiple cell reservoirs expressing unspliced HIV-1 gag-pol mRNA in patients on antiretroviral therapy.Future virology · 2012Article
- HIV-1 co-receptor usage: influence on mother-to-child transmission and pediatric infection.Journal of translational medicine · 2011Review
- Regulation of CCR5 expression in human placenta: insights from a study of mother-to-child transmission of HIV in Malawi.PloS one · 2010Article
- Plasmodium falciparum infection significantly impairs placental cytokine profile in HIV infected Cameroonian women.PloS one · 2009Article
- Role of placenta in the vertical transmission of human immunodeficiency virus.Journal of perinatology : official journal of the California Perinatal Association · 2009Review
- Differential expression of RDC1/CXCR7 in the human placenta.Journal of clinical immunology · 2009Article
- Host genetic determinants of human immunodeficiency virus infection and disease progression in children.Pediatric research · 2009Review
- Associations of chemokine receptor polymorphisms With HIV-1 mother-to-child transmission in sub-Saharan Africa: possible modulation of genetic effects by antiretrovirals.Journal of acquired immune deficiency syndromes (1999) · 2008Article
- Characterization of the main placental cytokine profiles from HIV-1-infected pregnant women treated with anti-retroviral drugs in France.Clinical and experimental immunology · 2007Article
- Impact of the placental cytokine-chemokine balance on regulation of cell-cell contact-induced human immunodeficiency virus type 1 translocation across a trophoblastic barrier in vitro.Journal of virology · 2005Article
- Age-related changes in expression of CXCR4 and CCR5 on peripheral blood leukocytes from uninfected infants born to human immunodeficiency virus type 1-infected mothers.Clinical and diagnostic laboratory immunology · 2004Article
- Memory CD4(+) T cells are the earliest detectable human immunodeficiency virus type 1 (HIV-1)-infected cells in the female genital mucosal tissue during HIV-1 transmission in an organ culture system.Journal of virology · 2002Article
- Susceptibility to human immunodeficiency virus-1 infection of human foreskin and cervical tissue grown in explant culture.The American journal of pathology · 2002Article
Corrections and comments
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Authors and funding
8 authors at 6 institutions in 2 countries.
Funding
Abstract
The role of placenta in vertical transmission is not yet fully understood. A protective role of the placenta during gestation is suggested by the finding that caesarian sections reduce the risk of transmission of human immunodeficiency virus (HIV)-1 from mother to child three- to fourfold. Here we investigated whether the immunological milieu of the placenta might be important in HIV-1 transmission. In situ imaging of immunohistochemically stained placenta sections and reverse transcriptase-polymerase chain reaction demonstrated a fourfold increase in CCR5:CXCR4 expression ratio in placentae from transmitting women compared to placentae from nontransmitting women. This chemokine receptor repertoire was consistent with an up-regulation of interleukin-4 and interleukin-10 expression in placentae from nontransmitting placentae compared to transmitting placentae. In situ imaging demonstrated that CCR5 and CXCR4 were expressed on placental macrophages and lymphocytes but not in trophoblasts. Simultaneous immunofluorescence/ultrasensitive in situ hybridization for HIV-1 gag-pol mRNA revealed that HIV-1 infects primarily CXCR4-expressing cells in placentae from nontransmitting women whereas predominantly CCR5-expressing cells were infected in placentae from transmitting women. These data are consistent with transmission of a homogeneous population of nonsyncytium-inducing HIV-1 isolates that use CCR5 as co-receptor.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.