ArticleThe American journal of pathology2000
Matrix metalloproteinase 9 promoter activity is induced coincident with invasion during tumor progression.
Article in The American journal of pathology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 104 citations in OpenAlex.
- A Novel Synthetic Compound (E)-5-((4-oxo-4H-chromen-3-yl)methyleneamino)-1-phenyl-1H-pyrazole-4-carbonitrile Inhibits TNFα-InducedInternational journal of molecular sciences · 2020Article
- Gene Expression Assays for Early-Stage Hormone Receptor-Positive Breast Cancer: Understanding the Differences.JNCI cancer spectrum · 2017Review
- Brain derived neutrophic factor (BDNF) coordinates lympho-vascular metastasis through a fibroblast-governed paracrine axis in the tumor microenvironment.Cancer cell & microenvironment · 2017Article
- Prognostic values of ERK1/2 and p-ERK1/2 expressions for poor survival in non-small cell lung cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
- Enhanced activation of matrix metalloproteinase-9 correlates with the degree of papillary thyroid carcinoma infiltration.Croatian medical journal · 2014Article
- Galectin-1 overexpression promotes progression and chemoresistance to cisplatin in epithelial ovarian cancer.Cell death & disease · 2014Article
- Article
- Saussurea lappa Clarke-Derived Costunolide Prevents TNF α -Induced Breast Cancer Cell Migration and Invasion by Inhibiting NF- κ B Activity.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Expression of MMP-9 and WAVE3 in colorectal cancer and its relationship to clinicopathological features.Journal of cancer research and clinical oncology · 2012Article
- The novel lupus antigen related protein acheron enhances the development of human breast cancer.International journal of cancer · 2012Article
- Establishment of field change by expression of cytokeratins 8/18, 19, and MMP-9 in an apparently normal oral mucosa adjacent to squamous cell carcinoma: A immunohistochemical study.Journal of oral and maxillofacial pathology : JOMFP · 2012Article
- Functional interrelationship between the WASF3 and KISS1 metastasis-associated genes in breast cancer cells.International journal of cancer · 2011Article
- Human leucine zipper protein sLZIP induces migration and invasion of cervical cancer cells via expression of matrix metalloproteinase-9.The Journal of biological chemistry · 2011Article
- The interferon-gamma-induced GTPase, mGBP-2, inhibits tumor necrosis factor alpha (TNF-alpha) induction of matrix metalloproteinase-9 (MMP-9) by inhibiting NF-kappaB and Rac protein.The Journal of biological chemistry · 2011Article
- Matrix metalloproteinases and their clinical relevance in urinary bladder cancer.Nature reviews. Urology · 2011Review
- An immortalization-dependent switch in integrin function up-regulates MMP-9 to enhance tumor cell invasion.Cancer research · 2008Article
- Effect of ablation or inhibition of stromal matrix metalloproteinase-9 on lung metastasis in a breast cancer model is dependent on genetic background.Cancer research · 2008Article
- The functional interplay between EGFR overexpression, hTERT activation, and p53 mutation in esophageal epithelial cells with activation of stromal fibroblasts induces tumor development, invasion, and differentiation.Genes & development · 2007Article
- Deciphering the molecular basis of breast cancer metastasis with mouse models.Reviews in endocrine & metabolic disorders · 2007Review
- Expression and prognostic relevance of activated extracellular-regulated kinases (ERK1/2) in breast cancer.British journal of cancer · 2005Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Matrix metalloproteinase 9 (MMP-9, also known as gelatinase B or 92-kd Type IV collagenase) is overexpressed in many human and murine cancers. We induced carcinomas in mice carrying a transgene that links the MMP-9 promoter to the reporter ss-galactosidase so that activation of the MMP-9 promoter would be indicated by ss-galactosidase. Mammary carcinomas were induced by mating the MMP-9 promoter reporter transgenic mice with mice carrying a transgene for murine mammary tumor virus promoter linked to polyoma middle T antigen, a transgene that leads to rapid development of mammary tumors in female mice. None of the hyperplastic mammary glands and none of the carcinomas in situ expressed ss-galactosidase. However, all invasive tumors had evidence of ss-galactosidase expression. In addition to the breast carcinomas, a malignant teratoma in a female and a papillary adenocarcinoma in the pelvic region of a male arose and were also ss-galactosidase positive. We also induced skin tumors in the mice with the MMP-9 reporter transgene with 7, 12-dimethylbenz[a]anthracene (DMBA) treatment followed by phorbol 12 myristate 13-acetate (TPA). None of the papillomas or in situ carcinomas showed any ss-galactosidase expression, but expression was seen in invasive carcinoma. Although normal skin epithelial cells did not express ss-galactosidase, we did find staining in a few cells at the duct of the sebaceous gland at the base of the hair follicles. The MMP-9 reporter transgene did not lead to expression in the alveolar macrophages, confirming that additional upstream sequences are required for expression in macrophages. These experiments have revealed that MMP-9 promoter activity is induced coincident with invasion during tumor progression. Furthermore, this indicates that the more proximal upstream elements of the promoter are sufficient for MMP-9 transcription during tumor progression.
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