ArticleBritish journal of cancer2000
Progressive genetic aberrations detected by comparative genomic hybridization in squamous cell cervical cancer.
Article in British journal of cancer, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 80 citations in OpenAlex.
- Human papillomavirus and cervical cancer: an insight highlighting pathogenesis and targeting strategies.Virusdisease · 2022Review
- SEC61G is upregulated and required for tumor progression in human kidney cancer.Molecular medicine reports · 2021Article
- Expression ofCancers · 2021Article
- Expression of 3q oncogeneOncology letters · 2019Article
- Identification of SEC62 as a potential marker for 3q amplification and cellular migration in dysplastic cervical lesions.BMC cancer · 2016Article
- Genome-wide screening of DNA copy number alterations in cervical carcinoma patients with CGH+SNP microarrays and HPV-FISH.International journal of clinical and experimental pathology · 2014Article
- Impact of gene dosage on gene expression, biological processes and survival in cervical cancer: a genome-wide follow-up study.PloS one · 2014Article
- Detention of HPV L1 Capsid Protein and hTERC Gene in Screening of Cervical Cancer.Iranian journal of basic medical sciences · 2013Article
- Cellular retinol binding protein 1 could be a tumor suppressor gene in cervical cancer.International journal of clinical and experimental pathology · 2013Article
- Loss of heterozygosity and copy number alterations in flow-sorted bulky cervical cancer.PloS one · 2013Article
- Difference of Genome-Wide Copy Number Alterations between High-Grade Squamous Intraepithelial Lesions and Squamous Cell Carcinomas of the Uterine Cervix.Korean journal of pathology · 2012Article
- HPV type-related chromosomal profiles in high-grade cervical intraepithelial neoplasia.BMC cancer · 2012Article
- Biomarkers of cervical dysplasia and carcinoma.Journal of oncology · 2012Article
- Amplified genes may be overexpressed, unchanged, or downregulated in cervical cancer cell lines.PloS one · 2012Article
- Inactivation of SLIT2-ROBO1/2 pathway in premalignant lesions of uterine cervix: clinical and prognostic significances.PloS one · 2012Article
- Intra-tumour genetic heterogeneity and poor chemoradiotherapy response in cervical cancer.British journal of cancer · 2011Article
- Fluorescence in situ hybridization markers for prediction of cervical lymph node metastases.The American journal of pathology · 2009Article
- Detection of genomic amplification of the human telomerase gene TERC, a potential marker for triage of women with HPV-positive, abnormal Pap smears.The American journal of pathology · 2009Article
- Integrated genomic and transcriptional profiling identifies chromosomal loci with altered gene expression in cervical cancer.Genes, chromosomes & cancer · 2008Article
- Microarray comparative genomic hybridization detection of chromosomal imbalances in uterine cervix carcinoma.BMC cancer · 2005Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genetic changes orchestrated by human papillomaviruses are the most important known factors in carcinogenesis of the uterine cervix. However, it is clear that additional genetic events are necessary for tumour progression. We have used comparative genomic hybridization to document non-random chromosomal gains and losses within a subset of 37 cervical carcinomas matched for clinical stage Ib, but with different lymph node status. There were significantly more chromosomal changes in the primary tumours when the lymph nodes were positive for metastases. The most frequent copy number alterations were loss of 3p, 11q, 6q and 10q and gain of 3q. The smallest areas of loss and gain on chromosome 3 were 3p14-22 and 3q24-26. The study identifies progressive DNA copy number changes associated with early-stage invasive cervical cancers with and without lymph node metastases, a factor of potential prognostic and therapeutic value.
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