ArticleOncogene2000
Synchronous and regulated expression of two AU-binding proteins, AUF1 and HuR, throughout murine development.
Article in Oncogene, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 44 citations in OpenAlex.
- NFκB (RelA) mediates transactivation of hnRNPD in oral cancer cells.Scientific reports · 2022Article
- Roles of Embryonic Lethal Abnormal Vision-Like RNA Binding Proteins in Cancer and Beyond.Frontiers in cell and developmental biology · 2022Review
- RNA-stabilizing proteins as molecular targets in cardiovascular pathologies.Trends in cardiovascular medicine · 2015Review
- Adaptive and maladaptive expression of the mRNA regulatory protein HuR.World journal of biological chemistry · 2013Review
- RNA binding proteins in the regulation of heart development.The international journal of biochemistry & cell biology · 2013Review
- AUF1 and HuR: possible implications of mRNA stability in thyroid function and disorders.Thyroid research · 2011Article
- Effect of chronic contractile activity on mRNA stability in skeletal muscle.American journal of physiology. Cell physiology · 2010Article
- HuR/methyl-HuR and AUF1 regulate the MAT expressed during liver proliferation, differentiation, and carcinogenesis.Gastroenterology · 2010Article
- Breast cancer epigenetics: from DNA methylation to microRNAs.Journal of mammary gland biology and neoplasia · 2010Review
- The RNA-binding protein Elavl1/HuR is essential for placental branching morphogenesis and embryonic development.Molecular and cellular biology · 2009Article
- FRET-detectable interactions between the ARE binding proteins, HuR and p37AUF1.RNA (New York, N.Y.) · 2007Article
- Mutant Cu/Zn-superoxide dismutase associated with amyotrophic lateral sclerosis destabilizes vascular endothelial growth factor mRNA and downregulates its expression.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Specific protein domains mediate cooperative assembly of HuR oligomers on AU-rich mRNA-destabilizing sequences.The Journal of biological chemistry · 2007Article
- Upf1/Upf2 regulation of 3' untranslated region splice variants of AUF1 links nonsense-mediated and A+U-rich element-mediated mRNA decay.Molecular and cellular biology · 2006Article
- HuR stabilizes vacuolar H+-translocating ATPase mRNA during cellular energy depletion.The Journal of biological chemistry · 2005Article
- p38 MAPK regulates IL-1beta induced IL-6 expression through mRNA stability in osteoblasts.Immunological investigations · 2004Article
- Highly selective actions of HuR in antagonizing AU-rich element-mediated mRNA destabilization.Molecular and cellular biology · 2002Article
- Post-transcriptional control of gene expression by AUF1: mechanisms, physiological targets, and regulation.Biochimica et biophysica actaReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The AUF1 (hnRNPD) and HuR (ELAV-like) proteins, potential trans-acting factors for regulated mRNA decay, bind in vitro to A+U-rich elements (AREs) found in the 3' untranslated region (3' UTR) of many labile transcripts. In an effort to determine whether these trans-acting factors are likely to play a role in embryogenesis, we have analysed their expression during mouse development both at the mRNA and protein levels. We show that AUF1 and HuR are expressed at all the developmental stages analysed from day 8.5 of embryonic development to adulthood. Expression levels are dynamic, varying between tissues and developmental stages. However, a strong positive correlation between AUF1 and HuR protein levels was observed in all examined tissues. Finally, we compared AUF1 and HuR expression with accumulation of one common target mRNA, c-myc. The similar spatio-temporal distribution of these proteins and of c-myc mRNA is in agreement with a potential concerted role in ARE-mediated control of mRNA stability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.