ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2000
Purinergic and adrenergic agonists synergize in stimulating vasopressin and oxytocin release.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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Who cites it
30 citing papers in PubMed, 89 citations in OpenAlex.
- Cell Type-Specific Expression of Purinergic P2X Receptors in the Hypothalamus.International journal of molecular sciences · 2025Review
- Purinergic P2 and glutamate NMDA receptor coupling contributes to osmotically driven excitability in hypothalamic magnocellular neurosecretory neurons.The Journal of physiology · 2021Article
- On P2X receptors in the brain: microvessels. Dedicated to the memory of the late Professor Geoffrey Burnstock (1929-2020).Cell and tissue research · 2021Review
- Activation of alpha-1 adrenergic receptors increases cytosolic calcium in neurones of the paraventricular nucleus of the hypothalamus.Journal of neuroendocrinology · 2019Article
- Purinergic receptor types in the hypothalamic-neurohypophysial system.Journal of neuroendocrinology · 2018Review
- Time-of-day-dependent expression of purinergic receptors in mouse suprachiasmatic nucleus.Cell and tissue research · 2017Article
- Role of fructose and fructokinase in acute dehydration-induced vasopressin gene expression and secretion in mice.Journal of neurophysiology · 2017Article
- Ghrelin-Induced Enhancement of Vasopressin and Oxytocin Secretion in Rat Neurohypophyseal Cell Cultures.Journal of molecular neuroscience : MN · 2016Article
- Extracellular ATP and other nucleotides-ubiquitous triggers of intercellular messenger release.Purinergic signalling · 2016Review
- Tomosyn Negatively Regulates Arginine Vasopressin Secretion in Embryonic Stem Cell-Derived Neurons.PloS one · 2016Article
- ATP stimulates rat hypothalamic sympathetic neurons by enhancing AMPA receptor-mediated currents.Journal of neurophysiology · 2015Article
- Supraoptic oxytocin and vasopressin neurons function as glucose and metabolic sensors.American journal of physiology. Regulatory, integrative and comparative physiology · 2014Article
- Purinergic and glutamatergic interactions in the hypothalamic paraventricular nucleus modulate sympathetic outflow.Purinergic signalling · 2013Article
- Potentiation of inhibitory synaptic transmission by extracellular ATP in rat suprachiasmatic nuclei.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- A1 noradrenergic neurons lesions reduce natriuresis and hypertensive responses to hypernatremia in rats.PloS one · 2013Article
- Astrocyte-neuron communication: functional consequences.Neurochemical research · 2012Review
- Diverse roles of G-protein coupled receptors in the regulation of neurohypophyseal hormone secretion.Journal of neuroendocrinology · 2012Review
- Regional expression of P2Y(4) receptors in the rat central nervous system.Purinergic signalling · 2011Article
- Bench-to-bedside review: Vasopressin in the management of septic shock.Critical care (London, England) · 2011Review
- Multiple alpha1-adrenergic receptor subtypes support synergistic stimulation of vasopressin and oxytocin release by ATP and phenylephrine.American journal of physiology. Regulatory, integrative and comparative physiology · 2010Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The A1 catecholamine neurons of the caudal ventrolateral medulla transmit hemodynamic information to the vasopressin (VP) neurons in the hypothalamus. These neurons corelease ATP with norepinephrine. Perifused explants of the hypothalamoneurohypophyseal system were used to investigate the role of these substances on VP release. ATP (100 micrometer) increased VP release 1.5-fold (p = 0.027). The response was rapid but unsustained. It was blocked by the P(2) receptor antagonist pyridoxal-phosphate-6-azophenyl-2',4'-disulphonic acid (PPADS). The alpha(1)-adrenergic agonist phenylephrine (PE; 100 micrometer) also increased VP release by 1.5-fold (p = 0.014). Again, the response was rapid and unsustained. However, simultaneous perifusion of explants with ATP (100 micrometer) and PE (100 micrometer) resulted in a threefold to fourfold increase in VP release, which was sustained for as long as 4 hr. There was a similar synergistic effect of ATP and PE on oxytocin release. Interestingly, the synergistic response was delayed approximately 40 min relative to the response to either agent alone. Several experiments were performed to elucidate the cellular mechanisms of this synergism. The effect was blocked by PPADS, a protein kinase C inhibitor (bisindolylmaleimide I HCl), and actinomycin, an inhibitor of gene transcription. These data suggest that P(2X) receptor activation, PKC-mediated phosphorylation, and gene transcription are required for the synergistic response. The marked synergism of these coreleased agents is probably important to achieve sustained increases in plasma VP in response to prolonged hypotension. These observations may also have broad applications to CNS function, because ATP may be coreleased at noradrenergic synapses throughout the CNS.
Indexed as
Identifiers
11102496PMC6773085W2095785527What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.